FUNDAMENTAL AND CLINICAL STUDIES ON SULTAMICILLIN
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概要
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Fundamental and clinical studies on sultamicillin (SBTPC), consisting of sulbactam (SBT) and ampicillin (ABPC), were performed.<BR>1) Fundamental studies<BR>The distribution of SBT and ABPC were measured in NZW rabbits after oral administration at a dose of 85mg/kg of SBTPC. SBT and ABPC were detected in serum, tongue, gingiva, parotid grand, submandibular gland, cervicalymphnodi, and dental pulp. Pharmacokinetic parameters were calculated from mean serum level of rabbits by two compartment model, and from each tissue level by three compartment model.<BR>2) Clinical results SBTPC was orally administered to 35 cases with infection in the oral surgical field.<BR>Overall efficacy rate was 81.8%.<BR>Thirty-three strains of micro-orgarisms were detected in 16 cases.<BR>Side effects were observed in 7 cases. Diarrhea and soft stool were observed in 6 cases and one case with gastralgia.<BR>Eosinophilia was noted in 1 case.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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