EXPERIMENTAL AND CLINICAL STUDIES ON DL-8280 IN URINARY TRACT INFECTIONS

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DL-8280, a new pyridone-carboxylic acid derivative was evaluated both experimentally and clinically on urinary tract infections, and following conclusions were obtained. 1) In the 17 registered strains, species of which are usually found in urinary tract infections, spectra of DL-8280 were broad. 2) The peak MICs of DL-8280 for ampicillin resistant E. coli (98 strains), and P.aeruginosa (51 (51 strains) and S.marcescens (28 strains) were fairly superior to that of NA. 3) The peak sprum concentration after oral administration of 200mg of DL-8280 was 1.65μg/ml at 3 hours, and half life was 4.5 hours. The peak urinary concentration was 254μg/ml at 2-4 hours, and urinary concentration level of 32μg/ml was observed at 12-24 hours. 4) Overall effectiveness rate of DL-8280 in acute simple cystitis was 100% and all cases showed excellent response. 5) Overall effectiveness rate of DL-8280 in complicated UTI was 95%. Even in the groups with indwelling catheters and mixed infections, over all effectiveness rate of DL-8280 were 100% respectively. 6) MICs of DL-8280 for strains isolated before treatments were less than 3.13μg/ml, and all strains were eradicated after treatments. 7) No subjective side effects and abnormal changes of laboratory examinations were observed. In conclusions, DL-8280 was suggested to be effective and safe antibiotic for the treatments of UTI.
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