腎の機能-8-Uremic toxins(講座)
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概要
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Bacteriological and clinical studies on DL-8280, a new synthetic antimicrobial agent of benzoxazine derivative, were performed and the following results were obtained.<BR>MICs of DL-8280 against clinically isolated strains of <I>E. coli</I>, <I>C. freundii</I>, <I>S. marcescens</I>, <I>P. aeruginosa</I> were almost the same as those of NFLX and were significantly superior to those of NA, PPA and MLX.<BR>DL-8280 was orally administered to healthy adult male volunteers at a dose of 200 mg. The maximum serum concentration of 2.83 μg/ml was obtained at 1 hour after administration. The half life of serum concentration was 3.13 hours. The maximum serum concentration of DL-8280 was higher than that of NFLX at the same dose level and bioavailability of DL-8280 was superior to that of NFLX. Serum concentration increased dose dependently. Urinary recovery of DL-8280 during 24 hours after administration was between 77.2 and 92.2%. In comparison with this high recovery rate of DL-8280, that of NFLX was only 35.4% during 24 hours after administration.<BR>DL-8280 was administered to 21 patients with various infections in the field of internal medicine at daily doses of 150-600 mg for 5-21 days. The clinical result was "excellent" in 3, "good" in 16, "fair" in 2 and the efficacy rate was 90.5%. Twelve out of 13 bacterial strains were eradicated and the eradication rate was 92.3%.<BR>Slight increase in serum alkaline-phosphatase was noted in one patient.<BR>From these results, it is concluded that DL-8280 is the extremely useful synthetic antimicrobial agent for the treatment of the infections in the field of internal medicine.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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