FUNDAMENTAL STUDIES ON TOBRAMYCIN
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概要
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Laboratory and experimental studies on tobramycin were performed, and the following results were obtained:<BR>1) Antibacterial activity<BR>The sensitivity of 70 strains of <I>Pseudomonas aeruginosa</I> isolated from burn wounds to tobramycin was measured, and compared with that to gentamicin and dideoxykanamycin B.<BR>Generally, in MIC values, the antibacterial activity of tobramycin was superior to that of gentamicin and dideoxykanamycin B.<BR>2) Tissue concentration<BR>After a single intramuscular injection of 5 mg tobramycin/kg to rabbits, the concentration of tobramycin in the serum and in the skin were determined.<BR>The peak of concentration in the serum was obtained after 30 minutes (average 186.6μg/ml). On the other hand, the peak of concentration in the skin was obtained after 60 minutes (average 28.0μg/ml). The tobramycin level in the skin was about 20% of that in the serum.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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