CLINICAL AND EXPERIMENTAL STUDIES ON CS-1170 IN UROLGICAL FIELDS
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1) Minimal inhibitory concentrations of CS-1170, cefoxitin (CFX) and cefazolin (CEZ) ware determined and compered on 141 strains isolated from urinary tract infections in the inoculum size of original overnight broth culture. Antimicrobial activities of CS-1170 were slightly weaker against <I>Staphylococcus aureus</I>, but stronger against <I>E. coli, Proteus vulgaris</I> and <I>Klebsiella</I> than CEZ, and as same as CFX. <I>Serratia</I> species were somewhat sensitive, but <I>Pseudomonas</I>, resistant to CS-1170.<BR>2) In a case with normal renal funtion, the blood level reached to the maximum (110 μg/ml) at the 30 minutes after one shot intravenous administration of CS-1170 1.0 g, decreased rapidly thereafter, and the urinary recovery rate was 99.0% within 6 hours.<BR>3) Tissue levels of CS-1170 in kidneys and prostates were determined wih the extirpated tissues of 2 renal calculi, 2 renal pelvic tumor and 7 prostatic hypertrophy patients, administrated 1.0-2.0g CS-1170 i. v. or d. i. at the operation time. Serum levels of CS-1170 in these patients were also determined in the same time. Mean renal tissue level of CS-1170 was 2.4 times the serum levels at the time of extirpaion, and renal cortical tissue levels were higher than medullary levels. Mean prostatic tissue level of CS-1170 was 19.0 % of the serum levels at the time of enuculation.<BR>4) Twenty nine cases with urogenital infections were treated with 1.0g to 2.0g of CS-1170 daily. Excellent or good results were obtained in 14 of 24 cases. Five cases were dropped out.<BR>5) Side effects were observed in only one of 29 cases (full feeling of stomach) Laboratory findings showed elevation of GPT in 3 cases and slight elevation of Al-p in 2 cases. But one case of elevation of GPT was not owing to the side effect of CS-1170.
- 公益社団法人 日本化学療法学会の論文
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