CS-1170の基礎的・臨床的検討 (CS-1170(CEFMETAZOLE:CMZ)論文特集)
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1) Antibacterial activity of CS-1170 was stronger than that of cefoxitin (CFX) and cefazolin (CEZ) against<I>E. coli, Klebsiella</I>and<I>Citrobacter freundii.</I>CS-1170 was equally effective to CFX and more effective than CEZ against<I>Serratia marcescens</I>and<I>Proteus morganii. Proteus mirabilis</I>was susceptible to all three of the drugs tested, whereas<I>Enterobacter cloacae</I>was mostly resistant to these drugs. Antibacterial activity of CS-1170 was slightly weaker than that of CFX against<I>Proteus rettgeri</I>and<I>Proteus inconstans</I>B, while it was stronger than that of CEZ. Strains resistant or nearly resistant to CER and CEZ (MIC: 25μg/ml or more) showed mostly stronger sensitivty to CS-1170, and CS-1170 was found to be superior to CFX in MIC against these strains.<BR>2) Blood concentration of CS-1170 was higher when diluted with serum than with buffer solution and its urinary recovery rate was high.<BR>3) CS-1170 was excreted more rapidly into bile than CEZ, besides the drug showed higher biliary concentration than CEZ.<BR>4) CS-1170 was administered clinically in 7 cases of respiratory tract infection, 4 cases of bile duct infection and 2 cases of urinary tract infection, and the results obtained were good clinical response in 11 cases and no response in 2 cases. From bacteriological viewpoint, pathogens were eradicated in 5 cases, microbes were substituted in 4 cases, no change was caused in 1 case, and the result was undetermined in 3 cases.<BR>5) No side effect was observed in any case treated by CS-1170. Hematological and hematochemical analyses did not show any change which would have been attributed to CS-1170. From the results mentioned above, CS-1170 may be considered to be a clinically useful antibiotic of cephamycin group.
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