PC-904による緑膿菌の形態変化について (PC-904(APALCILLIN:APPC)論文特集号)
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The effects of PC-904 and carbenicillin on the morphology of <I>Pseudomonas aeruginosa</I> E-2 were examined with the phase contrast microscope and scanning electron microscope. The following results were obtained.<BR>1. With a phase contrast microscope, exposure to PC-904 resulted in the fomation of marked filamentous cells. However, the spheroplast-like structures could not be observed by the treatment with PC-904. Exposure to carbenicillin resulted in the formation of spheroplast-like structures.<BR>2. With a scanning electron microscope, typical spheroplast-like structures could not be observed when PC-904 was allowed to act on <I>Ps.aeruginosa</I> E-2 cells.<BR>3. Possible influence on the ability to form spheroplasts was studied using stabilizers. As a result, it was found that spheroplasts were not formed wheri, PC-904 was allowed to act on <I>Ps.aeruginosa</I> E-2 cells.<BR>The morphological alterations of <I>Pseudomonas aeruginosa</I> E-2 treated with carbenicillin observed in this study were similar to those noted by PERKINS and PRIOR
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