外科領域におけるPC-904の基礎的,臨床的検討 (PC-904(APALCILLIN:APPC)論文特集号)
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Fundamental and clinical studies of PC-904 were investigated and the following results wereobtained.<BR>(1) Antibacterial activity<BR>The sensitivity of PC-904 and CBPC was examined in <I>Pseudomonas aeruginosa</I>. PC-904 was moreeffective than CBPC to <I>Pseudomonas aeruginosa</I>.<BR>2) Absorption and excretion<BR>A single intramuscular dose (20 mg/kg) in rabbit (n=3) gave a peak blood level of 10 μg/ml (themean value of 3 cases) 30 minutes after its administration. The biliary recovery rate was 51.6%within 6 hours.<BR>In two patients (with hepato-biliary disorder) with a single intramuscular dose of 250 mg, a peakblood level was 32.9 μg/ml and a peak bile level was 34.5 μg/ml (the mean value of 2 cases). Thebiliary recovery rate was 0.66% within 6 hours.<BR>(3) Clinical effectiveness<BR>PC-904 was administered to 14 patients with surgical infections and the results were good in 10 cases, fair in 2 cases and poor in 2 cases. Among untoward side effects, eruption was observed in onecase and an elevation of s-GOT and s-GPT in 2 cases. However, these levels returned to normalimmediately following discontinuation of the administration.
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