KW-1062ラット連続投与時の吸収・体内分布 (KW-1062論文特集号)
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Plasma and tissue concentrations of KW-1062 in rats, in comparison with gentamicin, were determined after multiple intramuscular administration of 10, 25 and 156 mg/kg for 5 or 10 days. Remarkable accumulation of KW-1062 after multiple administrations was observed in the kidney. The eliminaton of KW-1062 from the kidney was rather slow and the half-life was very long. No accumulation of KW-1062 in plasma was observed with multiple administrations, and the half-life was constantly about 20 to 30 minutes. Slight accumulation of KW-1062 was observed in other organs such as lung, liver and spleen. The elimination of gentamicin from the organs was in general slower than that of KW-1062.
- 公益社団法人 日本化学療法学会の論文
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