LABORATORY AND CLINICAL STUDIES ON SF-837
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The antibacterial activity of SF-837 and its therapeutic evaluation in the infections of each field were investigated, and the following results were obtained.<BR>1. The antibacterial activity of SF-837 was measured on 19 strains of <I>Staphylococcus aureus</I>, 9 strains of <I>Diplococcus</I> and 3 strains of <I>Enterococcus</I> isolated clinically. The MIC was 3.12 mcg/ml in 16 strains out of 19 strains of <I>Staphylococcus</I>, and less than 6.25 mcg/ml in 8 strains out of 9 strains of <I>Diplococcus</I>, while it was more than 100 mcg/ml in 3 strains of <I>Enterococcus</I>.<BR>In comparison with the usual macrolide antibiotics of which the tests were made simultaneously, the MIC of SF-837 showed to be almost the same as that of LM.<BR>2. SF-837 was administered at a daily dose of 6 capsules (containing 200 mg per capsule, a daily dose being 1, 200 mg) to the adults suffering mostly from the infections due to Gram-positive bacteria in each field, and the therapeutic results were obtained as follows.<BR>The antibiotic was effective in 36 cases out of 58 cases in the field of internal medicine, 13 cases out of21 cases in the field of surgery, 13 cases out of 14 cases in the field of orthopedics, and 27 cases out of 33 cases in the field of otorhinolaryngology, effective ratio being thus 60-90%. In contrast to this, the effective ratio was low as 30-50% for the urinary tract infections in the fields of urology and obstetrics and gynecology, that is, effective in 8 cases out of 23 cases and 1 case out of 2 cases respectively. In particular, the antibiotic was ineffective in all 5 cases of gonorrheal urethritis.<BR>3. The side effects of SF-837 were observed in 12 cases among all 151 cases. They consisted of digestive disorders such as anorexia, precordial pain, diarrhea, nausea and vomitting in 9 cases, stomatitis in 1 case, and skin eczema in 2 cases.<BR>The blood picture (erythrocyte-, leukocyte-and hemoglobin-counts) was examined before and after the antibiotic administration, and no abnormality was observed. The hepatic function (GOT, GPT, and alkaline phosphatase) was investigated in 21 cases, and the creatinine in 2 cases as well, and no abnormality was noticed.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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