BASIC AND CLINICAL STUDIES ON SULFOBENZYLPENICILLIN IN SURGICAL FIELD
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概要
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Following results were obtained by our basic and clinical studies on sulfobenzylpenicillin.<BR>1) Four decimal six to 13.0 mcg/ml of blood concentration and more than 2, 000 mcg/ml of maximal concentration in urine were obtained at an early stage after intramuscular injection of 500 mg in healthy adults.<BR>2) Forty-seven to 93% of the tested strains of <I>Proteus</I>, <I>E. coli</I> and <I>Staphylococci</I> were sensitive to sulfobenzylpenicillin with MIC of 12.5 mcg/ml or lower. MIC of sulfobenzylpenicillin ranged from 12.5 to 50 mcg/ml against 45% of the <I>Pseudomonas</I> strains tested. All the strains of <I>Klebsiella</I> were resistant to sulfobenzylpenicillin with MIC of 200 mcg/ml or higher.<BR>3) Sulfobenzylpenicillin was administered to 16 patients with surgical infections. Eleven cases responded to therapy, 2 failed to respond and 3 were unidentified. No particular side effects were observed.
- 公益社団法人 日本化学療法学会の論文
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