CLINICAL EXPERIENCE WITH FLUCLOXACILLIN IN GYNECOLOGICAL INFECTIONS
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概要
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Flucloxacillin (hereinafter referred to as MFI-PC) is a semi-synthetic penicillin which is active against gram-positive bacteria.<BR>The present authors made studies of MFI-PC for its sensitivity against those bacteria, absorption and clinical effectiveness.<BR>1. The mi nimal inhibitory concentration (M. I. C. ) of MFI-PC against <I>Staphylococci</I> obtained from patients ranged between 0. 09 and 3. 12 mcg/ml. The distribution curve of MIC showed the peak at a concentration of 0. 19 mcg/ml against those 30 strains of<I> Staphylococci.</I><BR>2. The peak serum level of MFI-PC was observed at on e hour following a single oral dose of 250 mg.<BR>3. Transfers of MFI-PC to mother's milk and umblical cord blood were very low.<BR>4. MFI-PC was proved to be effective in 15 out of the 16 patients with gynec ological infections. No marked side effects were encountered.
- 公益社団法人 日本化学療法学会の論文
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