PROGNOSTIC FACTORS IN THE HEPATIC METASTASIS FROM COLORECTAL CANCER AFTER HEPATECTOMY AND PREVENTIVE ARTERIAL INFUSION CHEMOTHERAPY

概要

論文の詳細を見る
To study the prognostic factors in patients with hepatic metastasis from colorectal cancer after hepatectomy and preventive arterial infusion chemotherapy (AIC). We examined outcomes in 42 patients treated with preventive AIC and evaluated possible prognostic factors by investigating clinicopathological variables with double staining with hematoxylin-eosin and Victoria blue for hepatic metastasis. The cumulative survival rates of patients with primary lesions smaller than 5cm were significantly greater than those of patients with primary lesions 5cm or larger in diameter. However, the site of primary lesion, Dukes' classification, and vessel invasion of the primary lesion did not affect survival. Although the cumulative survival rates of patients with vessel invasion in hepatic metastases were significantly lower than those of patients without vessel invasion, survival did not differ significantly on the basis of other variables. In addition, the incidence of recurrence was significantly higher in patients with vessel invasion of the primary lesion or lymph node metastasis than in other patients. These results suggest that vessel invasion of hepatic metastasis and that of primary lesions is significantly correlated with cumulative survival rates and recurrence in the remnant liver and strongly indicate an increased risk of recurrence.
日本癌病態治療研究会の論文