Further evaluation of factors affecting survival after resection in patients with gastric cancer and simultaneous distant metastases:A multivariate analysis

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Factors affecting survival after resection in patients with gastric cancer and simultaneous distant metastases were examined in the present study. A total of 300 patients who had undergone resection of gastric cancer, and who had distant metastases, were retrospectively analyzed with respect to survival using a multivariate analysis.Significant differences in survival time were found when univariate analysis was used to examine extent of lymphadenectomy (p<0.0001), surgical resectability (p<0.0001), depth of the tumor invasion (p=0.016), size of tumor (p=0.027) and liver metastasis (p<0.0001). Multivariate analysis using Cox's hazard model indicated that lymphadenectomy (hazard ratio: 1.469), surgical resectability (hazard ratio: 1.525), depth of the tumor invasion (hazard ratio: 1.530) and liver metastasis (hazard ratio: 2.062) were independent prognostic factors.The results of the present study suggest that the potential for cure in gastric cancer patients with distant metastases varies among patterns of metastasis, and that radical surgery with extended lymphadenectomy in attempts at the curative resection may contribute to increased survival of some of such patients.
日本癌病態治療研究会の論文