Relationship between metaplastic changes and occurrence of endocrin cells, lysozyme and lactoferrin in gallbladder carcinoma

概要

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The association between metaplastic changes seen in gallbladder cancer on the one hand and the appearance of endocrine cells, lysozyme and lactoferrin on the other was studied using serial sections of 50 cases of gallbladder cancer (9/50, early stage). The sections were examined histologically and immunohistochemically for the purpose of elucidating the histogenesis of gallbladder cancer. Gastrin-secreting, somatostatin-secreting and serotonin-secreting cells in cancer lesions were observed in each of 14 cases (28%), 10 cases (20%) and 15 cases (30%) and those in the non-cancerous mucosa each in 19 cases (38%), 16 cases (32%) and 19 cases (38%). Motilin-secreting cells were not observed in cancer lesions and were observed in only 2 cases (4%) in non-cancerous mucosa. The immunohistochemical activity of lysozyme and lactoferrin were observed in 29 cases (58%) and 6 cases (12%), respectively, in the cancer lesions and in 29 cases (58%) and 4 cases (8%), respectively, in the non-cancerous mucosa. No difference in the appearance rate of metaplastic cells was noticed between advanced and early gallbladder cancer. Metaplastic changes of endocrine cells and lysozyme are closely related to the development of gallbladder cancer. It is therefore possible that the intestinal metaplasia of gallbladder mucosa is an important lesion as regards carcinogenesis.
日本癌病態治療研究会の論文