Clinical features of long-surviving lung cancer patients without resection

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Clinico-pathological factors of long-surviving (more than 3 years) lung cancer patients who did not undergo resection (n=13) were compared with those of patients with resections. The latter group was comprised of short-survival (less than 3 years) (n=11) cases of pathological stagelA (T1N0M0) carcinomas. The average survival time of the long-surviving group was 51.8 months and that of the short-surviving group was 21.5 months. Chemotherapy was the most frequently used treatment (7/13, 53.8%) in the first group, in which CDDP was combined with radiotherapy. Pathological examinations from the group with resected stage lA primary tumors revealed microscopic blood vessel invasion in 6/11 cases (54.5%) and lymphatic vessel invasion in 2/11 cases (18.2%). The first relapse sites in this group were usually distant metastases. There were more females, and patients older than 75 years in the long-surviving group, and we also observed a greater number of squamous cell carcinomas in the first group (χ2-test, p<0.05). We therefore conclude that certain factors might relate to better prognosis, namely, being female and of a more advanced age, as well as the presence of squamous cell carcinoma in particular. Furthermoer, microscopic blood vessel invasion is one of the risk factors for distant metastases resulting in premature death following surgery.
日本癌病態治療研究会の論文