Transforming growth factor-β signaling pathway and its disruption in human cancer
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概要
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Recent findings regarding abnormalities of the TGF-β receptor and loss of its responsiveness to TGF-β in tumor cells have suggested that this receptor is one of the tumor suppressor genes. Abnormalities of the intracellular signal transduction pathway for TGF-β in tumor cells have also been reported, to which the TGF-β receptor contributes. In order to clarify the tumor suppression mechanism involving the TGF-β receptor, it has become necessary to gain a comprehensive understanding of the series of abnormalities in the signal transduction pathway. In this paper, we discuss the TGF-β receptor and the relationship of cancer to these abnormalities in the signal transduction pathway.
- 日本癌病態治療研究会の論文
日本癌病態治療研究会 | 論文
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