Decreases of Metallothionein and Aminopeptidase N in Renal Cancer Tissues.
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概要
- 論文の詳細を見る
Good molecular markers for investigating the biochemical differences between renal cancer and surrounding tissues have not yet been developed. Sixteen kidney samples (clear cell RCC) were investigated to determine the differences in the protein components between renal cancer and surrounding tissues, using HPLC analysis. The metallothionein (MT) and zinc levels were consistently lower in renal cancer tissues compared with in surrounding tissues. The mean concentration of MT in normal tissues surrounding renal tumors was about 15 times higher than that in cancer tissues. An immunohistochemical study confirmed that the expression of MT in renal cancer tissues was lower than that in adjacent normal tissues. The activities of aminopeptidases (APs) were significantly decreased in renal cancer tissues compared with in adjacent normal tissues. An immunohistochemical study and Western blot analysis confirmed that the expression of AP-N in renal cancer tissues was also lower than in adjacent normal tis-sues. These results suggest that the immunohistochemical detection of MT and AP-N could provide useful information as a pathological diagnostic tool for classifying renal cancer and surrounding tissues.
- 社団法人 日本生化学会の論文
著者
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Yamamoto Hajime
Toyama Prefectural Central Hospital
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Sugimura Yoshiki
Department Of Nephro-urologic Surgery And Andrology Mie University Graduate School Of Medicine
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Tatematsu Masae
Laboratory of Oncological Pathology, Aichi Cancer Center Research Institute
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Usui Shigeyuki
Loboratory of Pharmaceuties, Gifu Pharmaceutical University
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Ishii Kenichiro
Loboratory of Pharmaceuties, Gifu Pharmaceutical University
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Hirano Kazuyuki
Loboratory of Pharmaceuties, Gifu Pharmaceutical University
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