Identification of Phosphorylation Sites on Glial Fibrillary Acidic Protein for cdc2 Kinase and Ca2+-Calmodulin-Dependent Protein Kinase II.

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概要

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• We identified the phosphorylation sites of glial fibrillary acidic protein (GFAP) for cdc2 kinase and Ca2+-calmodulin (CaM)-dependent protein kinase II. GFAP was phosphorylated to _??_0.2 mol of phosphate/mol of GFAP by cdc2 kinase, and this phosphorylation did not induce disassembly of the filament structure. On the other hand, GFAP was phosphorylated to _??_1.9 mol of phosphate/mol of GFAP by Ca2+-CaM-dependent protein kinase II, and this phosphorylation did induce disassembly of the filament. Sequential analysis of the purified phosphopeptides revealed that only Ser8 on GFAP was phosphorylated by cdc2 kinase, whereas Ser13, Ser17, Ser34, and Ser389 on GFAP were phosphorylated by Ca2+-CaM-dependent protein kinase II.

• 社団法人 日本生化学会の論文

著者

• Matsuoka Yoichiro

  Department Of Pathology Ii Kansai Medical University

• Tanaka Jin

  Department Of Thoracic And Cardiovascular Surgery Anjo Kosei Hospital

• Tsujimura Kunio

  Department Of Infectious Diseases Hamamatsu University School Of Medicine

• Yamauchi Takashi

  Department Of Applied Physics Faculty Of Engineering Osaka University

• INAGAKI Masaki

  Department of Anatomy, Nihon University School of Medicine

• KUSUBATA Masashi

  Department of Food and Nutritional Environment, College of Human Life and Environment, Kinjo Gakuin University

• Sugiura Hiroko

  Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neurosciences

• Yamauchi Takashi

  Department of Biochemistry, Faculty of Pharmaceutical Sciences, University of Tokushima

• Ando Shoji

  Biophysics Unit, Aichi Cancer Center Research Institute

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