Inhibitory Effect of Allopurinol on the descending Po2 in vitro

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Xanthine oxidase does not exist in blood usually, but appears often in blood in pathological states such as hemorrhagic hypotensive rabbit, traumatic shock rat and severe patients after extracorporeal circulation and in I. C. U.<BR>Xanthine oxidase converts the hypoxanthine to xanthine to uric acid. It is reported that superoxide occures in the course of uric formation and therefore oxygen consumption increases. Superoxide and its derivatives, so called, active oxygens, oxidizes organic substances in the body and damages the cellular and subcellular membranes.<BR>In our experiment, the formation of uric acid in vitro was accelerated by the increase of both xanthine and xanthine oxidase, po2 descended and β-glucuronidase was released then, and these findings were inhibited by adding of allopurinol.
Japanese Society of Gout and Nucleic Acid Metabolismの論文