The Lowering Effect of Allopulinol on the Uric Acid and β-Glucuronidase of Cardiac Patients Undergoing Extracorporeal Circulation.

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We observed previously that allopurinol, which is used for the treatment of gout, had a life saving effect on account of the better survival rate of experimental traumatic shock rats and hemorrhagic shock rabbits. Fifteen patients undergoing open heart surgery which was considered to have the metabolic derangement similar to that of patients in shock state were investigated to evaluate the effect of allopurinol. Allopurinol was given orally 2mg/kg body weight twice before the start of nitrous oxide, oxygen and halothane anesthesia.<BR>In the control group containing ten patients who were not treated with allopurinol, serum uric acid increased, the lactate/pyruvate ratio rose and β-glucuronidase activity increased respectively after open heart surgery like in shock. While the metabolic changes of the fifteen patients pretreated with allopurinol were prohibited significantly although same tendency was observed.<BR>The heart beat of patients in the allopurinol group started spontaneously after extracorporeal circulation without using DC counter shock.<BR>We concluded that allopurinol is effective in preventive damage of cellular structures and derangements of metabolism of the patients performed open heart surgery.
Japanese Society of Gout and Nucleic Acid Metabolismの論文