口腔内科的発想による歯周病抗菌薬物療法—内服による抗菌薬は歯周病に有効か—

概要

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Periodontal disease as a biofilm infectious disease is considered. Periodontal disease-associated bacteria formed biofilm in periodontal pockets or on the surface of cementum. Planktonic bacteria from biofilm invade into periodontal tissues and lead to inflammation and destruction of tissues directly and indirectly by elicit host defense mechanism. Supragingival dental plaques (biofilm) are easily removed by professional mechanical tooth cleaning, while subgingival dental plaques and bacteria invading into periodontal tissues are difficult to be removed. Therefore, the development of novel methods for periodontal disease is needed to eliminate these biofilms efficiently. Hereby, we report the effect of antibiotics on in vitro biofilm model of periodontal disease and the systemic administration of azithromycin for the early-onset (aggressive) periodontitis.
Japanese Society of Oral and Maxillofacial Surgeonsの論文