Usefulness of Low-dose Methotrexate Monotherapy for Treating Sarcoidosis

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概要

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• Objective Methotrexate (MTX) is a cytotoxic agent that is commonly employed as an alternative to corticosteroids to treat sarcoidosis, although the proper use and efficacy of MTX as a single agent remain unclear. Methods The clinical records of patients newly diagnosed with sarcoidosis who were admitted to our institution between 2000 and 2009 were reviewed. Among these patients, 26 received 7.5 mg of MTX per week as a single agent, and the independent effects of MTX were analyzed. Results Six of the 26 patients (23%) exhibited an improvement of sarcoidosis-related lesions. The skin lesions demonstrated a relatively higher response rate (37%) than the pulmonary lesions (9%). Ten of the 26 patients (39%) experienced adverse effects, mostly mild hepatotoxicity. No severe adverse effects, including irreversible hepatotoxicity, were observed. Conclusion Although the efficacy of low-dose MTX monotherapy for sarcoidosis in this study was not high (23%), some patients exhibited definite improvements, and the drug proved to be safe, suggesting its possible benefits as a single agent for treating sarcoidosis.

• 社団法人 日本内科学会の論文

著者

• Terada Jiro

  Department Of Respirology Graduate School Of Medicine Chiba University

• Kono Chiyoko

  Department Of Respiratory Medicine Jr Tokyo General Hospital East Japan Railway

• Yamada Yoshihito

  Department Of Respiratory Medicine Jr Tokyo General Hospital East Japan Railway

• Tatsumi Koichiro

  Department Of Chest Medicine School Of Medicine Chiba University

• Yamaguchi Tetsuo

  Department Of Applied Physics Graduate School Of Engineering The University Of Tokyo:crest Jst

• Yamaguchi Yoko

  Department Of Biochemistry Nihon University School Of Dentistry

• Isshiki Takuma

  Department of Chest Medicine, Japan Railway Tokyo General Hospital, Japan

• Maemura Keita

  Department of Chest Medicine, Japan Railway Tokyo General Hospital, Japan

• Makita Kosuke

  Department of Chest Medicine, Japan Railway Tokyo General Hospital, Japan

• Takeshima Hideyuki

  Department of Chest Medicine, Japan Railway Tokyo General Hospital, Japan

• Hirasawa Yasutaka

  Department of Chest Medicine, Japan Railway Tokyo General Hospital, Japan

• Hosoki Keisuke

  Department of Chest Medicine, Japan Railway Tokyo General Hospital, Japan

• Suzuki Mika

  Department of Chest Medicine, Japan Railway Tokyo General Hospital, Japan

• Yamaguchi Yoko

  Department of Chest Medicine, Japan Railway Tokyo General Hospital, Japan

• Yamada Yoshihito

  Department of Chest Medicine, Japan Railway Tokyo General Hospital, Japan

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