γ-Mangostin from Garcinia Mangostana Pericarps as a Dual Agonist That Activates Both PPARα and PPARδ
スポンサーリンク
概要
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We tested the peroxisome proliferator-activated receptor (PPAR)δ agonistic activity of a Garcinia mangostana pericarp extract to develop a treatment for the metabolic syndrome, and demonstrated γ-mangostin to be an active compound on the basis of a luciferase reporter gene assay. γ-Mangostin induced the expression of the uncoupling protein-3 (UCP-3) gene which is related to energy expenditure and fat metabolism in L6 cells. We showed that γ-mangostin is a dual agonist that activates both PPARδ and PPARα. γ-Mangostin also induced the expression of acyl-CoA synthase and carnitine palmitoyl-transferase 1A genes in HepG2 cells. These results suggest the potential of γ-mangostin as a preventive agent of the metabolic syndrome.
著者
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Matsuura Nobuyasu
Department Of Life Science Faculty Of Science Okayama University Of Science
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Miyachi Hiroyuki
Department Of Chemistry Tokyo Gakugei University
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Kawada Teruo
Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University
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Takahashi Nobuyuki
Division Of Cardiology Shimane University Faculty Of Medicine
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KAWADA Teruo
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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IINUMA Munekazu
Faculty of Pharmaceutical Science, Gifu Pharmaceutical University
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AKAO Yukihiro
The United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University
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TOSA Hideki
Field & Device Co.
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GAMO Kanae
Department of Life Science, Faculty of Science, Okayama University of Science
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