Molecular Epidemiology of Human Metapneumovirus from 2005 to 2011 in Fukui, Japan
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概要
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To investigate the molecular epidemiology of human metapneumovirus (HMPV) infections in acute respiratory infections (ARI), we performed genetic analysis of the F gene in HMPV from patients with ARI in Fukui Prefecture from August 2005 to July 2011. HMPV was detected in 53 of 741 nasopharyngeal swabs (7.2%). Phylogenetic analysis helped us assign 31 strains to subgroup A2, 1 strain to subgroup B1, and 21 strains to subgroup B2. The prevalence of HMPV was peaked between January and June. A high degree of nucleotide identity was seen among subgroup A2 strains (95.6–100%) and subgroup B2 strains (97.5–100%). In addition, no positively selected sites (substitutions) were found in the F gene in these HMPV strains. The results suggest that the prevalent HMPV strains in Fukui were associated with various ARI in Japan during the investigation period.
著者
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ISHIGURO Fubito
Fukui Prefectural Institute of Public Health
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Tanaka Ryota
Department Of Neurology Juntendo University Urayasu Hospital
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Mizuta Katsumi
Yamagata Prefectural Inst. Public Health Yamagata
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Noda Masahiro
Infectious Disease Surveillance Center, National Institute of Infectious Diseases
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Tsukagoshi Hiroyuki
Gunma Prefectural Inst. Public Health And Environmental Sci. Gunma
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Kimura Hirokazu
Infectious Disease Surveillance Center, National Institute of Infectious Diseases
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Nakamura Masako
Fukui Prefectural Institute of Public Health and Environmental Science
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Hirano Eiko
Fukui Prefectural Institute of Public Health and Environmental Science
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ISHIGURO Fubito
Fukui Prefectural Institute of Health and Environmental Science, Fukui 910–8551, Japan
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