Molecular Epidemiology of Human Metapneumovirus from 2009 to 2011 in Okinawa, Japan
スポンサーリンク
概要
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To clarify the molecular epidemiology of human metapneumovirus (HMPV) in Okinawa Prefecture, located in a subtropical region of Japan, we performed genetic analysis of the F gene in HMPV from patients with acute respiratory infection from January 2009 to December 2011. HMPV was detected in 18 of 485 throat swabs (3.7%). Phylogenetic analysis showed that 17 strains belonged to subgroup A2 and 1 strain belonged to subgroup B1. We did not observe seasonal prevalence of HMPV during the investigation period. A high level of sequence identity was observed in the strains belonging to subgroup A2 (>95%), and no amino acid substitution was found compared with other strains detected in Japan and other countries. The pairwise distance values among the present strains belonging to subgroup A2 were short. Our results suggest that the predominant HMPV strains belonging to A2 are highly homologous and seasonal epidemics were not seen in Okinawa during the investigation period.
著者
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Noda Masahiro
Infectious Disease Surveillance Center, National Institute of Infectious Diseases
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Tsukagoshi Hiroyuki
Gunma Prefectural Inst. Public Health And Environmental Sci. Gunma
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Kimura Hirokazu
Infectious Disease Surveillance Center, National Institute of Infectious Diseases
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Kyan Hisako
Department of Biological Science, Okinawa Prefectural Institute of Health and Environment
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Azama Yasuhito
Department of Biological Science, Okinawa Prefectural Institute of Health and Environment
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Hamabata Hirotsune
Awase Daiichi Clinic
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Nidaira Minoru
Department of Biological Science, Okinawa Prefectural Institute of Health and Environment
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Taira Katsuya
Department of Biological Science, Okinawa Prefectural Institute of Health and Environment
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Kawaki Tatsuyoshi
Aozora Pediatric Clinic
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Gushi Kazuo
Gushi Kodomo Clinic
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Mahoe Youko
Department of Biological Science, Okinawa Prefectural Institute of Health and Environment
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Maeshiro Noriyuki
Department of Biological Science, Okinawa Prefectural Institute of Health and Environment
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Okano Shou
Department of Biological Science, Okinawa Prefectural Institute of Health and Environment
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Kudaka Jun
Department of Biological Science, Okinawa Prefectural Institute of Health and Environment
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