周期的圧縮刺激培養が再生軟骨組織の異方性に与える影響

概要

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Recently, tissue engineering therapy, culturing autologous chondrocytes in vitro to create three dimensional tissue for the replacement of damaged tissue, has been developed. Although the tissue engineering is a useful approach to reconstruct cartilage in vitro, the mechanical property of the engineered cartilage is not sufficient to replace natural cartilage. Within the natural cartilage, cells and collagen fibers, which are main components of the cartilage, align in response to the direction of cyclic deformations induced by daily walking or other activities. Due to this collagen fiber alignment, the cartilage has mechanical anisotropy. In this study, we focus on the beneficial effect of dynamic compressive loading on tissue regeneration for articular cartilage. The purpose of this study is to create mechanically anisotropic cartilage by compressive stimuli during the culture.