OS0905 誘電泳動を応用した細胞パターニングが再生軟骨の材料特性の異方性に与える影響(OS9-2 生体機能・材料(細胞),OS-9 生体機能・材料)

概要

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Recently, there have been efforts aimed at the repair and regeneration of damaged articular cartilage using tissue engineering. In tissue engineering therapy, cells are cultured in vitro to create a three dimensional (3-D) tissue designed to replace the damaged cartilage. Although the tissue engineering is a useful approach to regenerate cartilage, the mechanical property of the regenerated cartilage is not sufficient to replace natural cartilage. The purpose of this study is to create mechanically anisotropic cartilage using 3-D cell pattering technology. An anisotropic cartilaginous tissue was developed by cell patterning within hydrogel slabs using dielectrophoretic (DEP) forces. Tensile tests were performed to evaluate the material anisotropy. From the results of experiments the reconstructed tissue showed mechanical anisotropy in the tensile direction.
一般社団法人日本機械学会の論文
2011-07-16