Cardamonin Suppresses the Proliferation of Colon Cancer Cells by Promoting β-Catenin Degradation
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概要
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Aberrant accumulation of intracellular β-catenin and subsequent activation of β-catenin response transcription (CRT) in intestinal epithelial cells is a frequent early event during the development of colon cancer. Here we show that cardamonin, a chalcone isolated from Aplinia katsumadai Hayata, inhibited CRT in SW480 colon cancer cells that carry inactivating mutation in the adenomatous polyposis coli (APC) gene. Cardamonin also down-regulated intracellular β-catenin levels in SW480 cells without affecting its mRNA levels. Interestingly, pharmacological inhibition of the proteasome prevented the cardamonin-induced down-regulation of β-catenin. In addition, cardamonin suppressed the expression of cyclin D1 and c-myc, which are known β-catenin/T cell factor (TCF)-dependent genes. Moreover, cardamonin inhibited the growth of various colon cancer cells and induced G2/M cell cycle arrest in SW480 colon cancer cells. These findings indicate that cardamonin is a potential chemotherapeutic agent against colon cancer.
著者
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Oh Sangtaek
Department of Advanced Fermentation Fusion Science & Technology, Kookmin University
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Han Seung
Department of Biological Science, Inje University
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Park Seoyoung
Department of Advanced Fermentation Fusion Science & Technology, Kookmin University
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Gwak Jungsug
Department of Advanced Fermentation Fusion Science & Technology, Kookmin University
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Gwak Jungsug
Department of Advanced Fermentation Fusion Science & Technology, Kookmin University
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- Cardamonin Suppresses the Proliferation of Colon Cancer Cells by Promoting β-Catenin Degradation