Sasa quelpaertensis and p-Coumaric Acid Attenuate Oleic Acid-Induced Lipid Accumulation in HepG2 Cells
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概要
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In this study, we examined the effects of Jeju dwarf bamboo (Sasa quelpaertensis Nakai) extract (JBE) and p-coumaric acid (CA) on oleic acid (OA)-induced lipid accumulation in HepG2 cells. JBE and CA increased the phosphorylation of AMP-activated protein kinase (AMPK), and acetyl-CoA carboxylase (ACC) and the expression of carnitine palmitoyl transferase 1a (CPT1a) in OA-treated HepG2 cells. Additionally, these compounds decreased sterol regulatory element-binding protein-1c (SREBP-1c), fatty acid synthase (FAS), and OA-induced lipid accumulation, suggesting that JBE and CA modulate lipid metabolism in HepG2 cells via the AMPK activation pathway.
著者
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Kim Se-jae
Department Of Biology Jeju National University
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YOON Seon-A
Department of Biology, Jeju National University
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KO Hee-Chul
Jeju Sasa Development Agency, Jeju National University
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KANG Seung-Woo
Department of Biology, Jeju National University
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Yoon Seon-a
Department Of Biology Jeju National University
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Shin Hye-sun
Department Of Biology Jeju National University
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Kang Seong-il
Department Of Biology Jeju National University
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Kim Jeong-Hwan
Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University
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