高齢SHRにチオフェン投与を行なった後小脳顆粒細胞層内血管に出現したオスミウム好性物質
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概要
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To investigate thiophene-induced vascular damage in the rat cerebellum, we employed aged spontaneously hypertensive rats (SHR), which have vascular vulnerability. The animals were given a daily subcutaneous injection of 0.15ml of thiophene for 3 to 6 days. The cerebellum was then studied by light and electron microscopy, horseradish peroxidase (HRP) methods, and the quantitative determination of thiophene at sequential stages after administration. Well-demarcated regions of degeneration appeared, and these spread extensively in the cerebellar rostral folia and/or focally in the caudal folia. In these lesions, tangled villi or oil droplets with an osmiophilic homogeneous substance were found both within and/or outside the lumina of blood vessels, especially capillaries and venules. They were membrane-trophic and located in the degenerated endothelial cells and then disappeared from the lumina at a late stage. Platelet thrombi occupied the lumina of blood vessels in the pia mater and parenchyma from the early to late stage. A lack of reaction product and its extravascular leakage were clearly revealed using HRP. Thiophene and/or its metabolites were detected quantitatively at an early stage in the damaged cerebellum. These lesions were replaced by gliosis and/or cysts in surviving animals. It is concluded that thiophene or its metabolites cause vascular damage and granule cell degeneration, producing circulatory disturbance in aged SHR.
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日本毒性病理学会 | 論文
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