Oral Administration of Insulin with Chymotrypsin Inhibitors

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概要

• 論文の詳細を見る

• Enteric-coated capsules containing insulin (25 U/kg) and chymotrypsin inhibitor FK-401 (10 to 40 mg/kg) were administered orally to beagle dogs. FK-401 increased the intestinal absorption of insulin dose-dependently. When 40 mg/kg of FK-401 was co-administered with insulin, plasma IRI level reached to 366 μU/ml and plasma glucose fell to 59% compared with the level before. Such an effect was observed when insulin was co-administered with water-soluble chymotrypsin inhibitors FK-317 hydrochloride and FK-448, but was not when water-insoluble or slightly-soluble inhibitors chymostatin or FK-317 maleate was used. Some acids such as citric acid, lactic acid etc. enhanced the effect of chymotrypsin inhibitor on the absorption of insulin.

• Japan Society of Clinical Chemistryの論文

著者

• 佐藤 文泰

  興和株式会社東京研究所

• 藤井 節郎

  財団法人・大阪基礎医学研究奨励会

• 横尾 信夫

  興和株式会社・東京研究所

• 佐藤 文泰

  興和株式会社・東京研究所

関連論文

• 水溶性キモトリプシン阻害剤の合成研究(第2報)
• 水溶性キモトリプシン阻害剤の合成研究
• インスリンの消化管吸収に対するキモトリプシン阻害剤FK-448の増強作用
• Oral Administration of Insulin with Chymotrypsin Inhibitors
• The Effect of Chymotrypsin Inhibitors on the Intestinal Absorption of Insulin

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