The Effect of Chymotrypsin Inhibitors on the Intestinal Absorption of Insulin

概要

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The effect of chymotrypsin inhibitors on the intestinal absorption of insulin was investigated in conscious and unrestrained rabbits. Insulin at a dose of 25U/kg with 10mg/kg of chymotrypsin inhibitors was administered intraduodenally via an indwelled catheter. The blood glucose level was decreased following an administration of insulin in combination with each chymotrypsin inhibitor. The order of the effect on the intestinal absorption was related with the order of chymotrypsin inhibitory activity. Maximal decrease was observed when insulin was administered with such a strong inhibitor as FK 448, [4-(4-isopropylpipe-radinocarbonyl) phenyl 1, 2, 3, 4-tetrahydro-1-naphthoate methanesulfonate], whose IC<SUB>50</SUB> value was 7×10<SUP>-7</SUP>M, and the decrease of the glucose level was 25%, compared with the level before administration. The effect of inhibitors which inhibit both chymotrypsin and trypsin was almost the same with that of chymotrypsin specific inhibitors.
Japan Society of Clinical Chemistryの論文