The solubility of uric acid in urine -The solubility of urinary uric acid crystals-

概要

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The solubility of the uric acid crystals obtained from urine is reported to be more than two times as high as that of a commercial uric acid preparation. Therefore, we examined the solubilities of various uric acid preparations in buffer solutions with or without urea. The solubility of uric acid dihydrate was 1.6 to 1.8 times higher than the commercial anhydrous uric acid. It was found that urinary uric acid crystals obtained at pH 4 and at 4°Cwere the dihydrated form, and their solubility was 2.1 to 2.9 times higher than anhydrous uric acid. Therefore, the high solubility of the urinary uric acid crystals is partly explained by the hydration pattern of the crystals. The uric acid crystals obtained from ultrafiltered urine were also dihydrated when obtained at pH4 and at 4°C. However, these crystals became anhydrous after 7 days incubation at 37°C. On the other hand, the urinary uric acid crystals remained dihydrated after the incubation under same conditions. Therefore, it is suggested that the urinary macromolecules incorporated into the urinary uric acid crystals are responsible for the stability of uric acid dihydrate.
Japanese Society of Gout and Nucleic Acid Metabolismの論文