A study on fractional uric acid clearance in gouty patients treated with allopurinol

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Preliminary treatment of a few patients with allopurinol for 6 months resulted in a decrease in fractional uric acid clearance, which was already observed even after 3months of treatment. Therefore, we evaluated its effect on forty - one patients who were considered to have primary gout. The gouty patients were given allopurinol orally 100 mg twice a day for 6 months, and creatinine clearance (Ccr) and uric acid clearance (C<SUB>UA</SUB>), urine N-acetyl-β-Dglucosaminidase (NAG) and urine specific gravity based on Fishberg concentration test were measured before and 6 months after the beginning of the treatment. As the degree of deterioration on renal function may be associated with the alteration of the fractional uric acid clearance, the changes of Ccr and. CUA were compared with the value of renal function - related parameters before the treatment. In all groups, Ccr tended to elevate and CUA tended to fall after the treatment. However, the fall of fractional uric acid clearance was more attributed to the elevation of Ccr (p<0.001 )than the decrease of CUA, especially in the groups whose pretreatment Ccr was less than 60 ml/min. Therefore, we concluded that allopurinol may have a beneficial effect in preserving renal function.
Japanese Society of Gout and Nucleic Acid Metabolismの論文