Mechanism of alternation of the purine metabolism by intensive muscle exercise in man.:(I) High prevalance of gout and hyperuricemia in professional baseball playsers in Japan.

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Intensive muscle exercise occasionally lead to hyperuricemia and/or uricosuria in man. However, these mechanism is not quite uncle ar. Recently we had a oppotunity to study the prevalance of gout and hyperuricmia on two preofessional baseball teams in Tokyo. Unusual high incidence of gout hyperuricemia, increasing of serum CPK was revealed throughout this study. The results are following.<BR>1) The prevalance of gout 3,3 % and it of hyperuricemia was 34.0 %. The prevalance was up to 54.2 % among major Teague players. This incidence of gout was about 10 times higher than it of the s ame age normal population in Tokyo. In addition, serum creatini n e and BUNw as also more increased among these major league players than retired staff and or farm team players. (Table-2)<BR>2) 97.1 % of the subjects showed increasing of the serum CPK level and mean value of active playsers was four to eig ht times higher than normal adults.<BR>3) Serum uric acid highly increased during 5 mounths intensive muscle exercise among 20 farm-team players. (Table- 3)
Japanese Society of Gout and Nucleic Acid Metabolismの論文