Urolithiais as Complication in Gout

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We encountered 337 cases of gout for these ten years and found complication of urolithiasis in 44 cases (13.3%) of them. We studied these cases by dividing them into two groups: gout cases (G group) and complicated ones with urolithiasis (G+S group).<BR>The age of the first gouty attack was about 5 years earlier in G+S group than in G group. Both serum urate level and urinary urate excretion were significantly higher in G+S group than in G group. However, there was no significant difference between the two groups in creatinine clearance and uric acid clearance. Stones were obtained from 15 cases out of G+S group. The components of these stones were uric acid in 5 cases; uric acid and calcium oxalate in 2 cases; calcium oxalate in 4cases; and calcium oxalate and calcium phosphate in 4 cases. The results thus obtained were found considerably different from those reported by Gutman.<BR>These findings l e d us to consider as regards effects of hyperuricemia or hyperuricosuria on urolithogenesis that besides occurrence of uric acid stone in acidic urine, excessive monosodium urate in urine may accelerate formation of urinary stones consisting of such components as calcium stone or cystine stone.
Japanese Society of Gout and Nucleic Acid Metabolismの論文