Reduction of Serum Urate Level of Gouty Patients by Administration of Sobrerol and its Action Mechanism

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Three hundred mg of sobrerol were administered daily to 9patients with gout for 2 weeks, and serum urate level (Sua), urinary excretion of urate (Uua) and uric acid clearance (Cua)were determined before and after the sobrerol administration. Sua before and after the administration were 9.9 and 7.7 mg/dl, respectively, Uua were 0.54 and 0.35 mg/kg/hr, respectively, and Cua were 5.1 and 6.4 ml/min, respectively. These findings suggest that sobrerol reduced serum urate level by inhibiting urate production in gouty subjects. Sobrerol reduced significantly IMP contents in acid soluble fraction, but the agent did not inhibit hypoxanthine 14C incorporation into acid insoluble fraction of L1210 cells incubated in the presence of sobrerol, suggesting that the agent inhibited purine de novo syn thesis of the cells. Unlike allopurinol, sobrerol did not inhibit xanthine oxidase activity.