Potential Therapeutic Significance of HER-Family in Esophageal Squamous Cell Carcinoma

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概要

• 論文の詳細を見る

• Despite improvements in surgical techniques and perioperative management and surgery combined with chemotherapy and/or radiotherapy, the prognosis of esophageal squamous cell carcinoma (SCC) at an advanced stage remains poor. Therefore, for esophageal SCC patients, novel therapies such as small molecule inhibitors of tyrosine kinases (TKIs) and humanized monoclonal antibodies (mAbs) are very much needed.Esophageal SCC shows a relatively high incidence of EGFR (33%) and/or HER2(31%) overexpression. Two categories of anti-HER-family-targeting therapies have been in clinical development: small-molecule, HER-family-related TKIs such as Gefitinib,Erlotinib and Lapatinib, and humanized mAbs against the HER family represented by Cetuximab and Trastuzumab. Although there have been very few clinical trials of antiHER-family targeting drugs in esophageal SCC, some in vitro data suggested that the combination of Cetuximab and Trastuzumab could induce synergistic antiproliferative effects and additional antibody-dependent cellular cytotoxicity (ADCC) activities against esophageal SCC cells. A better understanding of the detailed mechanisms involved in EGFR and/or HER2 may help identify new therapeutic targets in esophageal SCC.

• Annals of Thoracic and Cardiovascular Surgery 編集委員会の論文

著者

• Kono Koji

  Department Of Inorganic Materials Research & Development The Environment And Process Technology

• Shabbir Asim

  Department Of Surgery University Surgical Centre National University Hospital

• Fujii Hideki

  First Department Of Surgery Department Of Medicine Yamanashi University

• Kono Koji

  Department of Surgery, National University of Singapore, Singapore

• Shabbir Asim

  Department of Surgery, National University of Singapore, Singapore

• Mimura Kousaku

  Department of Surgery, National University of Singapore, Singapore

• Yong Wei-Peng

  Department of Hematology-Oncology, National University of Singapore, Singapore

• Jimmy So

  Department of Surgery, National University of Singapore, Singapore

• KONO KOJI

  Department of Chemical Engineering, Osaka University

• Fujii Hideki

  First Department of Surgery, University of Yamanashi, Yamanashi, Yamanashi, Japan

• MIMURA Kousaku

  Department of Surgery, National University of Singapore

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