Measures to Counteract Oseltamivir Phosphate-Induced Changes on Electroencephalograms of Epilepsy-Prone El Mice

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概要

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• Oseltamivir phosphate has been reported to change spike discharges on electroencephalograms (EEGs) of epilepsy-prone El mice. The present study shows that two anti-epileptic drugs (sodium valproate and diazepam) counteract such alterations. Our observations suggest that short-term supplemental administration of sodium valproate or diazepam may be considered as an option when patients with epileptic tendencies but are not on a regular course of anti-epileptic drugs are taking oseltamivir phosphate.

著者

• FUJINO Osamu

  Department of Pediatrics, Nippon Medical School

• KUWABARA Kentaro

  Department of Pediatrics, Nippon Medical School

• FUJITA Takehisa

  Department of Pediatrics, Nippon Medical School

• Kawakami Yasuhiko

  Department Of Molecular Biology Kawasaki Medical School

• Kuwabara Kentaro

  Department Of Pediatrics Nippon Medical School

• Fujita Takehisa

  Department Of Pediatrics Nippon Medical School

• Fujino Osamu

  Departament Of Mathematics Faculty Of Science Kyoto University

• Koizumi Shinya

  Department Of Pediatrics Nippon Medical School Chiba Hokusoh Hospital

• Saito Kenichi

  Laboratory Of Environmental Health And Food Science Nippon Veterinary And Lief Science University

• Koizumi Shinya

  Department of Pediatrics, Nippon Medical School

• Baba Asami

  Laboratory of Environmental Health and Food Science, Nippon Veterinary and Life Science University

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