Measures to Counteract Oseltamivir Phosphate-Induced Changes on Electroencephalograms of Epilepsy-Prone El Mice
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概要
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Oseltamivir phosphate has been reported to change spike discharges on electroencephalograms (EEGs) of epilepsy-prone El mice. The present study shows that two anti-epileptic drugs (sodium valproate and diazepam) counteract such alterations. Our observations suggest that short-term supplemental administration of sodium valproate or diazepam may be considered as an option when patients with epileptic tendencies but are not on a regular course of anti-epileptic drugs are taking oseltamivir phosphate.
著者
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FUJINO Osamu
Department of Pediatrics, Nippon Medical School
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KUWABARA Kentaro
Department of Pediatrics, Nippon Medical School
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FUJITA Takehisa
Department of Pediatrics, Nippon Medical School
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Kawakami Yasuhiko
Department Of Molecular Biology Kawasaki Medical School
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Kuwabara Kentaro
Department Of Pediatrics Nippon Medical School
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Fujita Takehisa
Department Of Pediatrics Nippon Medical School
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Fujino Osamu
Departament Of Mathematics Faculty Of Science Kyoto University
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Koizumi Shinya
Department Of Pediatrics Nippon Medical School Chiba Hokusoh Hospital
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Saito Kenichi
Laboratory Of Environmental Health And Food Science Nippon Veterinary And Lief Science University
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Koizumi Shinya
Department of Pediatrics, Nippon Medical School
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Baba Asami
Laboratory of Environmental Health and Food Science, Nippon Veterinary and Life Science University
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