N-Type Ca2+ Channel Blockade Prevents Sudden Death in Mice with Heart Failure
スポンサーリンク
概要
- 論文の詳細を見る
<B>Background:</B> Increased sympathetic nerve activities cause arrhythmogenicity in patients with chronic heart failure. N-type Ca<SUP>2+</SUP> channel (NCC) modulates sympathetic nerve activity by regulating the release of noradrenalin at sympathetic nerve terminal. The ability of NCC blockade to prevent lethal arrhythmias associated with heart failure has never been tested, however. <B>Methods and Results:</B> We compared effects of cilnidipine (Cil), dual N- and L-type Ca<SUP>2+</SUP> channel blocker, with those of nitrendipine (Nit), a selective L-type Ca<SUP>2+</SUP> channel blocker, in a cardiac-specific, dominant-negative form of neuron-restrictive silencer factor transgenic mice (dnNRSF-Tg), a mouse model of dilated cardiomyopathy leading to sudden arrhythmic death. Hemodynamic and echocardiographic analyses showed no significant difference among the control, Cil, and Nit groups. In contrast, Cil dramatically improved the survival rate (p<0.001) and reduced ventricular arrhythmia (p<0.05) among dnNRSF-Tg mice, compared with control vehicle or Nit. Cil improved the imbalance in autonomic nerve activity assessed by heart rate valiability, and also reduced the increased urinary excretion of noradrenalin seen in dnNRSF-Tg, whereas Nit did not. <B>Conclusions:</B> NCC blockade ameliorated disturbed autonomic nerve function and improved survival in a mouse model of dilated cardiomyopathy and sudden death. Our findings suggest NCC blockade is a potentially useful approach to preventing sudden cardiac death in patients with heart failure.
著者
-
Kuwahara Koichiro
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
-
Nakagawa Yasuaki
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
-
Kinoshita Hideyuki
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
-
Kuwabara Yoshihiro
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
-
Yamada Chinatsu
Department Of Cardiology Kurashiki Central Hospital
-
Yamada Yuko
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
-
Shibata Junko
Department Of Cardiology International Medical Center Of Japan
-
Nishikimi Toshio
Department Of Hypertension And Cardiorenal Medicine Dokkyo Medical University
-
Nakagawa Yasuaki
Department Of Electronics Tohoku Institute Of Technology
-
Kuwabara Yoshihiro
Department Of Medicine And Clinical Science Kyoto University Graduate School Of Medicine
-
Kinoshita Hideyuki
Department Of Biological And Chemical Engineering Gunma University
-
Nakao Kazuyasu
Department Of General Surgery Osaka Police Hospital
-
Nakao Kazuwa
Department Of Endcrinology And Metabolism Kyoto University Graduate School Of Medicine
-
Usami Satoshi
Department Of Education The University Of Tokyo Laboratory Of Educational Psychology
-
Minami Takeya
Department of Medicine and Clinical Science, Kyoto Graduate School of Medicine
-
Yamada Yuko
Department of Cardiology, National Cerebral and Cardiovascular Center
-
Minami Takeya
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
関連論文
- PE-533 The Combination of Selective Aldosterone Blocker and CCB Exerts Additive Protective Effects against Salt-sensitive Hypertension-induced Cardiovascular Injury(PE089,Cardiomyopathy/Hypertrophy (Basic) (M),Poster Session (English),The 73rd Annual Scie
- PJ-056 Two-dimensional Speckle Tracking Echocardiography is Useful for the Detection of the Location of Kent Bundle in Wolff-Parkinson-White Syndrome(PJ010,Echo/Doppler (New Technology) 2 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of
- OE-323 Functional Assay of von Willebrand Factor (VWF) and VWF-cleaving Protease (ADAMTS13) Activity in Acute Myocardial Infarction(Acute myocardial infarction, clinical(pathophysiology)(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeti
- PJ-321 Clinical Factors Affecting Serum Potassium Concentration(Heart failure, clinical(16)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-157 Analysis of the Change of Von Willebrand Factor and ADAMTS13 Concentration following Radiofrequency Catheter Ablation of Atrial Fibrillation(PJ027,Arrhythmia, Others (Clinical/Pathophysiology) 2 (A),Poster Session (Japanese),The 73rd Annual Scienti
- OE-295 Coronary Microvessel Spasm is a Frequent Cause of Myocardial Ischemia in Postmenopausal Women with Angina-like Chest Pain(OE50,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Oral Presentation (English),The 73rd Annual Scientif
- PJ-588 Plasma Von Willebrand Factor and ADAMTS13 Concentrations in Atrial Fibrillation(Arrhythmia, diagnosis/Pathophysiology/EPS(10)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-165 An Important Role of p300 on Mitochondrial Gene Expression and Function and Tolerance to Ischemia in the Heart(PE028,Heart Failure, Basic (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- FRS-007 Functional inhibition of p300 in the post-natal heart leads to mitochondrial dysfunction and cell death in mice(Novel Pathophysiological Mechanisms of Heart Failure(M),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Ci
- PE-441 Essential Role of p300 in Post-natal Cardiac Mitochondrial Gene Expression and Maintenance of Normal Cardiac Function(Heart failure, basic-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Smoking cessation is associated with increased plasma adiponectin levels in men
- PJ-530 Post Procedural Creatinine Increase is Associated with Endothelial Dysfunction in Patients with Early Stage of Chronic Kidney Disease(PJ089,Atherosclerosis (Clinical/Pathophysiology) 1 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meet
- PJ-176 Hypercholesterolemia and Hypoadiponectinemia are Risk Factors for Coronary Plaque Vulnerability(PJ030,Metabolic Syndrome 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Silent cerebral microbleeds associated with arterial stiffness in an apparently healthy subject
- PJ-530 Post Procedural Creatinine Increase is Associated with Endothelial Dysfunction in Patients with Early Stage of Chronic Kidney Disease(PJ089,Atherosclerosis (Clinical/Pathophysiology) 1 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meet
- Waveform of Ophthalmic Artery Doppler Flow Predicts the Severity of Systemic Atherosclerosis
- IS040 Positive association between essential hypertension and Glu298Asp polymorphism in the endothelial nitric oxide synthase gene
- OE-001 Impact of Cytochrome P450 2C19 Polymorphism on Platelet Function after Treatment with Clopidogrel in Japanese Patients of Coronary Artery Disease(OE01,Cardiovascular Pharmacology (Clinical) (H),Oral Presentation (English),The 73rd Annual Scientific
- PJ-557 Automatically Assessed P-wave Duration and Amplitude were Associated with Left Ventricular Hypertrophy and Brain Natriuretic Peptide(PJ094,ECG/Body Surface Potential Mapping/Holter 2 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting
- OE-033 Pioglitazone Modulates Acute Inflammatory Response and Attenuates Infarct Size Caused by Myocardial Ischemia-reperfusion in Mice with Metabolic Abnormality(OE06,Myocardial Ischemia-reperfusion (Basic) (IHD),Oral Presentation (English),The 73rd Annu
- High Ratio of Myeloid Dendritic Cells to Plasmacytoid Dendritic Cells in Blood of Patients With Acute Coronary Syndrome
- Effects of gastric medicines on gastroduodenal injury in patients with stable angina during antiplatelet therapy
- DPE-007 Protein Kinase G-mediated Inhibition of TRPC6 Channel Activity Participates in Anti-hypertrophic Effect of Cardiac Natriuretic Peptides(DPE02,Heart Failure, Basic (M),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japan
- OE-172 A Novel NRSF-binding Partner Zfp90 Negatively Regulates the Repression Activity of NRSF, a Critical Regulator of Cardiac Fetal Gene Program(OE29,Molecular Biology Myocardium (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The
- PJ-760 Plasma Level of Leptin is a Predicting Factor for Chronic Restenosis after Drug-eluting Stent Implantation(PJ128,Coronary Revascularization, PCI (DES) 5 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation
- PJ-305 Antihypertensive Effect of Ghrelin in Dahl Salt-sensitive Rats(PJ052,Hypertension, Basic (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-464 Plasma Endoglin Level is a Predicting Factor for Cardiovascular Events in Patients with Chronic Coronary Artery Disease(PE078,Angina Pectoris (Clinical) (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation S
- PJ-684 Cilostazol Increases ADAMTS13 Expression in Endothelial Cells(PJ115,Thromboembolism/Antithrombotic Therapy/Thrombolysis (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- DPJ-014 Increased Platelet Aggregation Associated with Coronary Microvascular and Renal Dysfunction in Patients with Normal Coronary Arteriograms(DPJ03,Kidney/Renal Circulation/CKD (H),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting o
- OJ-129 Statin-use and Increase of Adiponectin Enhance Stabilization and Regression of Coronary Arterial Plaques Characterized by Low- and High-density Lipoprotein Cholesterols(OJ22,ACS/AMI (Clinical/Pathophysiology) (IHD),Oral Presentation (Japanese),The
- 7 Clinical Value of a Novel Cardiac Image Fusion Software CardIQ for Three-dimensional Integration of SPECT and 64-slice CT Coronary Angiography(Frontiers in Coronary Imaging,Symposium 15 (SY-15) (A),The 73rd Annual Scientific Meeting of The Japanese Circ
- PJ-671 Abdominal Obesity is a Significant Determinant of Endothelial Dysfunction in High Risk Patients with or without Metabolic Syndrome(Diabetes / Obesity / Metabolic syndrome(13)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Jap
- PJ-336 Metabolic syndrome causes impaired microcirculation and myocardial perfusion during coronary intervention(Intravascular endoscopy/Intravascular ultrasound(06)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulatio
- PJ-124 Pentraxin 3, a Novel Plasma Inflammatory Marker, is Significantly Associated with Congestive Heart Failure(Heart failure, clinical(14)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-119 Synergistic Interaction of Plasma BNP and Glucose Levels for Enhanced Risk for Cardiovascular Re-attacks in Patients with Heart Failure(Heart failure, clinical(13)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circu
- Relationship between plasma cardiotrophin-1 and left ventricular remodeling in patients with first acute myocardial infarction
- Relationship between plasma level of cardiotrophin-1 and left ventricular mass index in patients with dilated cardiomyopathy
- PJ-242 Analysis of Plaque Composition in Culprit Lesion Obtained by Directional Coronary Atherectomy : From Viewpoints of Gender Difference(PJ041,Atherosclerosis (Clinical/Pathophysiology/Treatment/Diagnosis) (IHD),Poster Session (Japanese),The 73rd Annua
- PJ-042 Associations of Plasma Pentraxin 3, TNF α, and MCP-1 Concentrations with Cardiovascular Disease in Patients with Chronic Kidney Disease(PJ007,Kidney/Renal Circulation/CKD 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Jap
- Possible involvement of Atypical Protein Kinase C in Aldosterone-induced-Angiotensin-Converting-Enzyme Gene Expression in Cultured Neonatal Rat Cardiocytes
- IS007 Interleukin-1b Induces Myocyte Hypertrophy and Production of B-type Natriuretic Peptide
- PE-175 Ambulatory Blood Pressure Variability Correlates with Arterial Damage in Treated Hypertensive Patients(PE030,Hypertension, Clinical 1 (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Genetic Polymorphisms of L-Type Calcium Channel α1c and α1D Subunit Genes are Associated With Sensitivity to the Antihypertensive Effects of L-Type Dihydropyridine Calcium-Channel Blockers
- PE-219 Imbalance of Cholesterol Synthesis and Absorption in Excess Obesity(PE037,Obesity/SAS 1 (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Lack of Association between T^→C Mutation in the 5'-Flanking Region of the Endothelial Nitric Oxide Synthase Gene and Essential Hypertension
- FRS-116 Circulating Class A Macrophage Scavenger Receptor Positive Circulating Mononuclear Cells Were Specifically Increased in Patients with Acute Coronary Syndrome(Novel Aspects for Acute Coronary Syndrome(IHD),Featured Research Session,The 72nd Annual
- PJ-504 The Combination of Anemia and B-type Natriuretic Peptide can Strongly Predict Future Adverse Outcomes in Patients with Chronic Heart Failure(Heart failure, clinical-15, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Blockade of Angiotensin II Type 1 Receptor Improves the Arrhythmia Morbidity in Mice With Left Ventricular Hypertrophy
- Association of CT Dinucleotide Repeat Polymorphism in the 5'-Flanking Region of the Guanylyl Cyclase (GC)-A Gene with Essential Hypertension in the Japanese
- Genetic Disruption of Angiotensin II Type 1a Receptor Improves Long-Term Survival of Mice With Chronic Severe Aortic Regurgitation
- FRS-094 MRTF-A, a Rho-dependent Co-activaotr of SRF, Mediates Mechanical Stress-induced Hypertrophic Gene Reprogramming(FRS19,Genetic Abnormalities in Cardiac Hypertrophy and Cardiomyopathy (M),Featured Research Session (English),The 73rd Annual Scientifi
- PE-305 The actin-binding Protein STARS is a Cytoskeletal Intermediary between MEF2 and SRF during Cardiac Remodeling(Cardiomyopathy, basic/clinical-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-210 TRPC6 Fulfills a Calcineurin Signaling Circuit During Pathological Cardiac Remodeling(Cardiac hypertrophy, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-308 Plasma and Tissue Levels of Proangiotensin-12 in Spontaneously Hypertensive Rats (SHR) Treated with Inhibitors of the Reninangiotensin (RA) System(PJ052,Hypertension, Basic (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Jap
- PE-543 Estimated Glomerular Filtration Rate Has Synergistic and Incremental Predictive Value over B-type Natriuretic Peptide in Patients with Heart Failure(Heart failure, clinical(12)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Ja
- PE-341 Improvement of Endothelial Function is a Potential Clinical Target for Heart Failure Patients with Systolic or Diastolic Dysfunction(Heart failure, clinical(10)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulati
- In-Vivo Electrophysiological Study in Dominant-Negative NRSF Transgenic Mice : Ventricular Arrhythmia Vulnerability and Sudden Cardiac Death
- PJ-730 Relationship between N-terminal Pro Brain Natriuretic Peptide and Cardiac Function in Patients with Cardiovascular Disease Associated with Chronic Kidney Disease(PJ123,Kidney/Renal Circulation/CKD 6 (H),Poster Session (Japanese),The 73rd Annual Sci
- OJ-098 Expression of Cannabinoid Receptor 1 in Human Coronary Atheroma and Anti-inflammatory Effects of Rimonabant(Atherosclerosis, basic(02)(IHD),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Angiotensin II Type 1 Receptor Improves the Arrhythmia Morbidityin Mice with Left Ventricular Hypertrophy
- Angiotensin II-Induced Ventricular Hypertrophy and Extracellular Signal-Regulated Kinase Activation Are Suppressed in Mice Overexpressing Brain Natriuretic Peptide in Circulation
- PE-047 Increased Platelet Aggregation Associated with Coronary Microvascular Dysfunction in Patients With Normal Coronary Arteriograms(Coronary circulation, basic/clinical(02)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese
- OJ-021 Blockade of T-type Calcium Channel Reduced the Arrythmogenicity in the Dominant Negative NRSF Transgenic Mice(Heart failure, basic-2 (M) OJ4,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Soc
- SOCS1/JAB Likely Mediates the Protective Effect of Cardiotrophin-1 Against Lipopolysaccharide-Induced Left Ventricular Dysfunction In Vivo
- PJ-622 Significance of a novel interaction between NRSF and classII HDAC involved in the induction of ANP gene expression by Endothelin-1(Cardiac Hypertrophy, Basic and Clinical 2 (M) : PJ104)(Poster Session (Japanese))
- OJ-481 Beneficial Effects of Brain Natriuretic Peptide Overexpression in Cardiac Remodeling after Myocardial Infarction in Mice(Old Myocardial Infarction/Remodeling 1 (IHD) : OJ59)(Oral Presentation (Japanese))
- Role of Renin-Anglotensin System in Cardiac Remodeling after Aortic Regurgitation in Mice
- ERK5 Plays a Critical Role in Cardiotrophin-1-Induced Hypertrophy of Neonatal Rat Ventricular Myocytes
- Evidence for Cardiac Myocyte Regeneration in Injured Myocardium by Bone Marrow Derived Cells
- JAB/SOCS1 and CIS3/SOCS3 inhibit hypertrophic response to cardiotrophin-1 independent of STAT3 suppression in neonatal rat ventricular myocytes
- Overxepression of brain natriuretic peptide mediates cardiac matrix metalloproteinase induction and induces cardiac rupture after acute myocardial infarction in mice
- Inhibition of histone deacetylase selectively induces expression of cardiac embryonic genes that contain neuron-restrictive silencer element in cultured ventricular myocytes
- Disruption of natriuretic peptides receptor A leads to higher mortality and exaggerated left ventricular remodeling after myocardial infarction in mice
- Genetic disruption of angiotensin II type 2 (AT2) receptor worsened short-term survival after acute myocardial infarction in mice
- Pathophysiological Significance of T-type Ca^ Channels : Transcriptional Regulation of T-type Ca^ Channel : Regulation of CACNA1H by Neuron-Restrictive Silencer Factor
- PE-540 ASK2 Deficient Mice Have Elevated Blood Pressure with Cardiac Hypertrophy and Remodeling Mediated by Angiotensin II(PE091,Molecular Biology (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-135 ASK1 and ASK2 are Differentially Involved in Salt Induced Blood Presssure Elevation and Cardiac Injury(OJ23,Hypertension, Basic (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-918 Aldosterone-mediated Cardiovascular Remodeling and Vascular Endothelial Dysfunction in Mice,Through Apoptosis Signal-Regulating Kinase 1 (ASK1)(Neurohumoral factors(02)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese
- PJ-519 The Combination of PPAR-gamma Agonist and ARB Exerts Additive Protective Effects against Hypertensive Cardiovascular Injury by More Suppressing ROS(Hypertension, basic(04)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japane
- PJ-634 Apoptois Signal-Regulating Kinase 1 (ASK1) Plays a Pivotal Role in Aldosterone-induced Cardiac Inflammation, Fibrosis and Vascular Endothelial Dysfunction(PJ107,Cardiomyopathy/Hypertrophy (Basic, Clinical) (M),Poster Session (Japanese),The 73rd Ann
- PE-019 Angiotensin II-Induced Reactive Oxygen Species via eNOS Uncoupling, Rather than NADPH Oxidase, is Involved in Hypertensive Cardiovascular and Kidney Disease(PE004,Hypertension, Basic (H),Poster Session (English),The 73rd Annual Scientific Meeting o
- OJ-133 Angiotensin II is Involved in Salt-Induced Neuronal Cell Oxidative Stress and Apoptosis in Hypertensive Rats : Crucial Role of NADPH Oxidase(Cerebrovascular circulation / Stroke(01)(H),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting
- OJ-096 Improvement of Vascular Endothelial Dysfunction by Tetrahydrobiopterin(BH_4) Supplementation Inhibits the Progresstion of Hypertensive Diastolic Heart Failure(DHF)(Heart failure, basic(02)(M),Oral Presentation(Japanese),The 72nd Annual Scientific M
- 1 Protective Effects of Natriuretic Peptide System in Pathological Cardiac Remodeling(Peptide Hormones in Cardiovascular Diseases,Topic 4 (TP-4) (H),Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-280 Characteristics of Coronary Spasm Associated With Negative U Wave in Electrocardiography(ECG/Body surface potential mapping/Holter(01)(A),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-676 Long-Term Clinical Benefits of Sirolimus Eluting versus Bare Metal Stents in Patients with Chronic Kidney Disease(PJ114,Coronary Revascularization, PCI (DES) 4 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circu
- PJ-268 Clinical Outcomes of Sirolimus Eluting Stents in Patients with Chronic Kidney Disease(PJ045,Coronary Revascularization, PCI (DES) 1 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Pump failure death and sudden cardiac death in patients with cardiac dysfunction : A search for prognostic predictive factors-A long-term follow-up study
- Transcriptional Regulation of the Pacemaker Channel HCN4 (Excitation-contraction Coupling/Ion Channel 2 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- The effect of edaravone on plasma monocyte chemoattractant protein-1 levels in patients with acute myocardial infarction
- PJ-209 Estimated Creatinie Clearance is a Useful Factor to Evaluate the Prognosis of Heart Failure(Heart failure, clinical-15 (M) PJ35,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Relationship between Plasma Level of Cardiotrophin-1 and Prognosis in Patients with Dilated Cardiomyopathy
- Pathophysiological Remodeling of Mouse Cardiac Myocytes Expressing Dominant Negative Mutant of Neuron Restrictive Silencing Factor
- New Molecular Mechanisms for Cardiovascular Disease:Transcriptional Pathways and Novel Therapeutic Targets in Heart Failure
- Regulation and significance of atrial and brain natriuretic peptides as cardiac hormones
- New Molecular Mechanisms for Cardiovascular Disease : Transcriptional Pathways and Novel Therapeutic Targets in Heart Failure
- N-Type Ca2+ Channel Blockade Prevents Sudden Death in Mice with Heart Failure
- Inhibition of HCN Overexpressed in Failing Heart of Dilated Cardiomyopathy Mouse Model by Ivabradine Prevents Sudden Arrhythmic Death
- Transcriptional Regulation of the Fetal Cardiac Gene Program
- Transcriptional Regulation of the Fetal Cardiac Gene Program