Effects of Olmesartan in Hypertensive Patients with History of Paroxysmal Atrial Fibrillation

スポンサーリンク

概要

• 論文の詳細を見る

• <B>Background:</B> J-RHYTHM II study has shown that treatment of hypertension suppressed episodes of paroxysmal atrial fibrillation (AF) in patients with hypertension with the history of AF. The effect of lowering blood pressure by olmesartan on AF burden, vascular inflammation markers, and autonomic nerve activity is unknown. <B>Methods:</B> In this prospective study of 40 cases of essential hypertension with history of paroxysmal atrial fibrillation, including 17 with new administration of olmesartan (Group A) and 23 with substituting olmesaltan for other antihypertensive drug (Group B), Holter electrocardiogram, ambulatory blood pressure monitoring and a panel of vascular inflammation markers were performed before and after 6-month administration of olmesartan. All patients were followed by using daily portable ECG recordings in spite of symptoms (twice ECG/day), and were encouraged to submit further ECGs in any case of symptoms. <B>Results:</B> In group A, blood pressure was significantly lower (Systolic blood pressure; 147±15 mmHg vs 127±16 mmHg, p<0.05, Diastolic blood pressure; 79±11 mmHg vs 73±9 mmHg, p<0.05), but AF burden was not decreased (11±25% vs 6±13%, p=NS) at the follow-up period with olmesartan 14.4±6.5 mg. In group B, blood pressure was not significantly changed and AF burden was not decreased. In both groups, vascular inflammation markers and autonomic function did not significantly change. In conclusion, Treatment with olmesartan was not associated with a reduction in the incidence of recurrent AF.

• 日本不整脈学会の論文

著者

• Fujii Eitaro

  Department Of Cardiology Mie University Graduate School Of Medicine

• Nakamura Mashio

  Department Of Cardiology And Nephrology Mie University Graduate School Of Medicine

• Sugiura Shinya

  Department Of Cardiology Mie University Graduate School Of Medicine

• Senga Michiharu

  Department Of Cardiology Mie University Graduate School Of Medicine

• Ito Masaaki

  Department Of Agricultural Chemistry Yamagata University

• Senga Michiharu

  Department of Cardiology and Nephrology, Mie University Graduate School of Medicine

• Sugiura Shinya

  Department of Cardiology and Nephrology, Mie University Graduate School of Medicine

• Fujii Eitaro

  Department of Cardiology and Nephrology, Mie University Graduate School of Medicine

関連論文

• Overexpression of Myosin Phosphatase Reduces Ca2+ Sensitivity of Contraction and Impairs Cardiac Function
• Correlation Between Late Gadolinium Enhancement and Diastolic Function in Hypertrophic Cardiomyopathy Assessed by Magnetic Resonance Imaging
• Vegetation With Ventricular Septal Defect Detected by Cardiac Magnetic Resonance Imaging
• PE-152 Quantification of Left Ventricular Mechanical Dyssynchrony in Normal, Hypertrophied, and Dilated Myocardium Quantified by Speckle-Tracking Strain Echocardiography(PE026,Cardiac Function (Clinical) 1 (M),Poster Session (English),The 73rd Annual Scie
• DPJ-028 Impaired Right Ventricular Contraction and Relaxation in Patients with Aortic Stenosis Quantified by Echocardiography Speckle-Tracking Strain and Strain Rate Imaging(DPJ05,Echo/Doppler (Myocardium) (I),Digital Poster Session (Japanese),The 73rd An
• OE-379 Quantification of Left Ventricular Contraction and Relaxation in Patients with Diastolic Heart Failure by Speckle-Tracking Strain and Strain Rate Echocardiography(OE64,Heart Failure (Diagnosis) (M),Oral Presentation (English),The 73rd Annual Scient
• 4 Cardiac Function and Hemodynamics in Diastolic Heart Failure by Using Left Ventricular Pressure-volume Analysis(Pathophysiology and Therapeutic Strategy of Diastolic Dysfunction in Heart Failure,Plenary Session 4 (PL-4) (IHD),The 73rd Annual Scientific
• Hemodynamic Characteristics of Patients with Diastolic Heart Failure and Hypertension
• PJ-497 Three-Directional Quantification of Left Ventricular Relaxation Abnormalities in Hypertensive Left Ventricular Hypertrophy with Preserved Systolic Function by Speckle-Tracking Echocardiography(Echo/Doppler(16)(I),Poster Session(Japanese),The 72nd A
• PE-277 Coupling of Left and Right Ventricular Function Stratified by Plasma Brain Natriuretic Peptide Level in Patients with Previous Myocardial Infarction(Cardiac function, basic/clinical(03)(M),Poster Session(English),The 72nd Annual Scientific Meeting
• 2 Utility of Yu-Index to Quantify Left Ventricular Systolic and Diastolic Dyssynchrony(Recent Development of Ultrasound Myocardial Imaging,Topic 3 (TP-3) (I),Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Prevention of venous thromboembolism according to the guidelines of a domestic manual
• 2 Long-term Clinical Outcome after Intramuscular Implantation of Bone Marrow Mononuclear Cells (TACT Trial) in Patients with Chronic Limb Ischemia(Regenerative Therapy for Peripheral Artery Disease,Symposium 12 (SY-12) (I),The 73rd Annual Scientific Meeti
• High throughput comparative genomic hybridization array analysis of multifocal urothelial cancers
• Management of concomitant ureteral carcinoma in situ at radical cystectomy
• Venous Thromboembolism : Deep Vein Thrombosis With Pulmonary Embolism, Deep Vein Thrombosis Alone, and Pulmonary Embolism Alone(Hypertension/Pulmonary Circulation)
• PJ-743 Incidence and Clinical Characteristics of Venous Thromboembolism(Pulmonary circulation(04)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OE-114 Incidence of Pulmonary Embolism in Psychiatric Wards in Japan(Thromboembolism/Antithrombotic therapy/Thrombolysis(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Pulmonary embolism is an important cause of death in young adults
• Incidence and Clinical Predictors of Deep Vein Thrombosis in Patients Hospitalized With Heart Failure in Japan
• PJ-680 Comparison of Sirolimus-Eluting Stents (SES) and Paclitaxel-Eluting Stents (PES) in Diabetic Patients(PJ114,Coronary Revascularization, PCI (DES) 4 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Socie
• PJ-472 Elevated cGMP Plays Important Role in Acute Vasodilatory Effect of Sildenafil(PJ080,Pulmonary Circulation 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PE-054 Paclitaxel-Eluting Stent Midterm Outcome Analysis : Investigation of Predictive Factors of Restenosis and Analysis of Stent Neointimal Proliferation with IB-IVUS(PE009,Coronary Revascularization, PCI (DES) 2 (IHD),Poster Session (English),The 73rd
• OJ-119 Hybrid Therapy with Catheter Ablation and Antiarrhythmic Drug for Chronic Atrial Fibrillation(OJ20,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 2 (A),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation S
• 2 Current Efficacy and Future Direction of Sildenafil in the Management for Pulmonary Arterial Hypertension(The Drug of Choice for Idiopathic Pulmonary Arterial Hypertension,Roundtable Discussion 5 (RT-5) (H),The 73rd Annual Scientific Meeting of The Japa
• Unusual Pulmonary Embolism : Septic Pulmonary Embolism and Amniotic Fluid Embolism
• Cancer and Pulmonary Embolism : Thrombotic Embolism, Tumor Embolism, and Tumor Invasion Into a Large Vein(Clinical Investigation)
• Cut-off values of D-dimer and soluble fibrin for prediction of deep vein thrombosis after orthopaedic surgery
• Elevated levels of soluble fibrin in patients with venous thromboembolism
• Exaggerated Hypertensive Response to Exercise in Patients with Diastolic Heart Failure
• OE-112 Association of Vitamin K Epoxide Reductase Complex 1 (VKORC1) Variants with Warfarin Dose Requirements in VTE Patients(Thromboembolism/Antithrombotic therapy/Thrombolysis(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the J
• PJ-827 High Plasma Level of Factor VIII : Important Risk Factor for Venous Thromboembolism(Pulmonary circulation-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-089 Age- and Gender-Related RV function in Normal Population Quantified by Speckle-Tracking Global Strain and Strain Rate Imaging(Echo/Doppler(12)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PE-584 The Effect of Thrombolysis is Predictable by the Initial Response of D-dimer Test for the Treatment of Deep Vein Thrombosis(Thromboembolism/Antithrombotic therapy/Thrombolysis(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the
• PE-454 Impact of Chronic Kidney Disease on Myocardial Perfusion Reserve determined by Quantitative Analysis of Myocardial Perfusion MRI(MRI/MRA(02)(I),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PE-313 Altered Myocardial Perfusion Reserve in Patients with Metabolic Syndrome Determined by Quantitative Analysis of Myocardial Perfusion MRI(Diabetes/Obesity/Metabolic syndrome(06)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Ja
• 3 Oral Sildenafil Therapy for Pulmonary Arterial Hypertension(Current Therapeutic Strategy for Pulmonary Hypertension,Roundtable Discussion 6 (RT-06) (H),Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• The Gunther-Tulip Retrievable IVC Filter : Clinical Experience in 118 Consecutive Patients
• OJ-077 Quantification of Global Right Ventricular Contraction-Relaxation Coupling in Previous Myocardial Infarction by Speckle-Tracking Global Strain and Strain Rate Imaging(Cardiac function, basic/clinical(02)(M),Oral Presentation(Japanese),The 72nd Annu
• Identification of Cyclophilin B-derived Peptides Capable of Inducing Histocompatibility Leukocyte Antigen-A2-restricted and Tumor-specific Cytotoxic T Lymphocytes
• PJ-798 Randomized Comparison of Ticlopidine versus Cilostazol for Antiplatelet Therapy after Sirolimus-Eluting Stent Implantation(Thromboembolism/Antithrombotic therapy/Thrombolysis-5 (H) PJ141,Poster Session (Japanese),The 70th Anniversary Annual Scienti
• 4 Current Status and Future of Japanese Guidelines for the Prevention of Pulmonary Thromboembolism(Pulmonary Thromboembolism in Japan: Present and Future,Roundtable Discussion 9 (RT9) (H),The 70th Anniversary Annual Scientific Meeting of the Japanese Circ
• Unique Myocardial Fibrosis Pattern by Late Gadolinium Enhanced Magnetic Resonance Imaging in a Patient With Isolated Noncompaction of the Ventricular Myocardium
• PJ-066 Cardiac Magnetic Resonance Imaging can Reveal a Variety of Myocardial Damage in Patients with Takotsubo Cardiomyopathy(PJ011,CT/MRI (Myocardium) 4 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• OJ-087 Incremental Prognostic Values of Serum Tenascin-C Levels to Late Gadolinium Enhancement by Cardiac Magnetic Resonance in Patients with Dilated Cardiomyopathy(OJ15,Cardiomyopathy/Hypertrophy (Clinical) (M),Oral Presentation (Japanese),The 73rd Annua
• 5 Assessment of Cardiac Function and Perfusion with Pharmacological Stress MDCT(A New Horizon of Cardiac CT-Beyond Lumen Visualization-,Symposium 13 (SY-13) (IHD),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Response to : Study of Left Ventricular Long Axis Function in Patients with Hypertensive Response to Exercise
• 2 Long Term Prognostic Value of Stress Perfusion CMR and Late Gadolinium Enhanced CMR for Prediction of Major Adverse Cardiac Events(Symposium 14 (SY-14) (I) New Horizon of CT, MR and PET in Diagnostic Cardiac Imaging,Special Program,The 72nd Annual Scien
• Patients with a Hypertensive Response to Exercise Have Impaired Left Ventricular Diastolic Function
• PJ-147 Preprocedural TIMI Flow and Myocardial Blood Flow After Primary Angioplasty in Patients with Acute Myocardial Infarction(Acute coronary syndrome, basic/clinical-8, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PE-143 Patients with a Hypertensive Response to Light Exercise Have Impaired Left Ventricular Diastolic Function in the Absence of Resting Hypertension(Cardiac function, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Soci
• OE-303 Characterization of Longitudinal and Circumferential Early Diastolic Expansion and Its Relation to Systolic Contraction in Patients with Left Ventricular Hypertrophy(Echo/Doppler-03, The 71st Annual Scientific Meeting of the Japanese Circulation So
• OE-200 Serum Tenascin-C Levels Predict Hospitalization for Heart Failure in Patients with Dilated Cardiomyopathy(Heart failure, clinical-02, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• The association of protein S Tokushima-K196E with a risk of deep vein thrombosis
• PJ-550 Pulse Wave Velocity and Upstroke Time as a Predictor of the Presence of Peripheral Arterial Disease(Peripheral circulation/Vascular disease(08)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Expression of functional Toll-like receptor 2 on human epidermal keratinocytes
• Homogeneous epithelial γδ T cell repertoire of the skin is shaped through peripheral selection
• OJ-142 Serum Intact Parathyroid Hormone levels can predict hospitalization for heart failure(Heart failure, clinical(05)(M),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OE-097 Quantification of Arterial Blood Pressure Fluctuation by Spectral Analysis in Patients with Sleep Apnea Syndrome(Hypertension, clinical-01, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OE-246 Diagnosis of Pulmonary Embolism with Multi-Detector Helical CT : Comparison with Pulmonary Angiography(Pulmonary circulation-1 (H) OE42,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• Overexpression of Myosin Phosphatase Reduces Ca^ Sensitivity of Contraction and Impairs Cardiac Function
• Changes in Vertebral Wedging Rate Between Supine and Standing Position and its Association With Back Pain : A Prospective Study in Patients With Osteoporotic Vertebral Compression Fractures
• Adenosine Triphosphate-sensitive Micro-reentrant Atrial Tachycardia Originating from the Crista Terminalis in a Patient with Chronic Renal Failure due to Thrombotic Thrombocytopenic Purpura
• Identification of Carboxyl Residues in Pepstatin-Insensitive Carboxyl Proteinase from Pseudomonas sp. 101 that Participate in Catalysis and Substrate Binding
• Cloining and Expression of an Isovaleryl Pepstatin-Insensitive Carboxyl Proteinase Gene from Xanthomonas sp. T-22
• Infection-induced urethral defect treated by urethral reconstruction with a radial forearm flap
• Substrate Specificities of Pepstatin-Insensitive Carboxyl Proteinases from Gram-Negative Bacteria
• Purpura with Cold Urticaria in a Patient with Hepatitis C Virus Infection-Associated Mixed Cryoglobulinemia Type III : Successful Treatment with Interferon-β
• Papuloerythroderma of Ofuji Associated with Strongyloidiasis
• Efficacy of linear block at the left atrial roof in atrial fibrillation
• Catheter Ablation of a Complex Atrial Tachycardia after Surgical Repair of Tetralogy of Fallot Guided by Combined Noncontact and Contact Mapping
• How long is strict bed rest necessary after renal biopsy?
• PJ-707 Advantages and Issues of the Retrievable IVC Filter : From the Clinical Experiences with Gunther Tulip Filter in 145 Consecutive Patients(Pulmonary circulation-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Beneficial Acute Effects of Rho-Kinase Inhibitor in Patients With Pulmonary Arterial Hypertension
• Big Mitogen-Activated Protein Kinase : A New Player in Vascular Remodeling
• Two-Dimensional Toda Lattice Equations
• Gene expression of Sh3d19, a novel adaptor protein with five Src homology 3 domains, in anagen mouse hair follicles
• The activity of fatty acid synthase of epidermal keratinocytes is regulated in the lower stratum spinousum and the stratum basale by local inflammation rather than by circulating hormones
• High transepidermal water loss induces fatty acid synthesis and cutaneous fatty acid-binding protein expression in rat skin
• Immunohistochemical distribution of cutaneous fatty acid-binding protein in human skin
• Hypertension impairs myocardial blood perfusion reserve in subjects without regional myocardial ischemia
• Ventricular Fibrillation Intervals Depend on Left Ventricular Size as Well as Effective Refractory Period in Patients with Left Ventricular Scar
• Electrical Dissociation between Low Left Atrium and Coronary Sinus Musculature and the Sustenance of Atrial Fibrillation
• Shortening of Conduction Time Over Arborized Atrioventricular Accessory Pathway With Mahaim Fibers Physiology Just Before Interruption During Radiofrequency Ablation
• Multidetector-Row Computed Tomography-Based Clinical Assessment of Fondaparinux for Treatment of Acute Pulmonary Embolism and Acute Deep Vein Thrombosis in Japanese Patients
• High Plasma Level of Factor VIII : An Important Risk Factor for Venous Thromboembolism
• The Utility of Transtelephonic Electrocardiograms for Detecting Arrhythmia Recurrences after Radiofrequency Catheter Ablation for Atrial Fibrillation
• Early Results of Rheolytic Thrombectomy in Patients With Proximal Deep Vein Thrombosis
• Neurogenic Stress Cardiomyopathy Following Aneurysmal Subarachnoid Hemorrhage in a Very Elderly Patient : Case Report
• Current Status and Trends in the Treatment of Acute Pulmonary Thromboembolism
• Impaired Myocardial Perfusion Reserve in Patients With Fatty Liver Disease Assessed by Quantitative Myocardial Perfusion Magnetic Resonance Imaging
• Observational Investigation of Thrombolysis With the Tissue-Type Plasminogen Activator Monteplase for Acute Pulmonary Embolism in Japan
• Heart Failure Exacerbation Associated with Newly Developed Atrioventricular Dyssynchrony after Chemical Conversion to a Sinus Rhythm in a Patient Receiving Cardiac Resynchronization Therapy
• Characterization of Inductively-Coupled RF Plasma Sources with Multiple Low-Inductance Antenna Units
• Use of Corticosteroids in the Treatment of Cholesterol Crystal Embolism after Cardiac Catheterization: A Report of Four Japanese Cases
• Guidelines for Secondary Prevention of Myocardial Infarction (JCS 2011) : Digest Version
• Effects of Olmesartan in Hypertensive Patients with History of Paroxysmal Atrial Fibrillation
• Effect of CFAE Ablation on Clinical Outcome in Patients with Persistent Atrial Fibrillation Undergoing Hybrid Therapy of Ablation and Bepridil
• Current Venous Thromboembolism Management and Outcomes in Japan:– Nationwide The Japan Venous Thromboembolism Treatment Registry Observational Study –
• Echocardiographic estimation of pulmonary capillary wedge pressure using the combination of diastolic annular and mitral inflow velocities

もっと見る 閉じる

スポンサーリンク