A Case of Acute Kidney Injury with Marked Hyperuricemia During Mizoribine Administration
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概要
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A 52-year-old woman was diagnosed with Blau syndrome and rheumatoid arthritis and was treated with prednisolone and methotrexate. Joint pain and skin ulcers were poorly controlled; therefore, mizoribine (MZ; 150 mg/day) was administered once daily from March 2011. In early July 2011, the patient was hospitalized because of acute kidney injury (AKI) and acute pancreatitis. We reasoned that AKI resulted from hyperuricemia during MZ administration because serum concentrations of uric acid (31.6 mg/dL) and MZ (trough level, 5.14 μg/mL) were markedly elevated on admission. MZ should be administered with caution because of the risk of marked hyperuricemia leading to AKI.
著者
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SHINZATO KEN
Shinzato Nephro-Clinic
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Obata Yoko
Second Department Of Internal Medicine Nagasaki University Graduate School Of Biomedical Sciences
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Kohno Shigeru
Second Dep. Of Internal Medicine Nagasaki Univ. Graduate School Of Biomedical Sciences Nagasaki Univ
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Nishino Tomoya
Second Department Of Internal Medicine Nagasaki University
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Yamashita Hiroshi
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Obata Yoko
Second Department of Internal Medicine, Nagasaki University of Medicine, Japan
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Nishino Tomoya
Second Department of Internal Medicine, Nagasaki University of Medicine, Japan
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Shinzato Takeaki
Department of Nephrology, Sasebo General Hospital, Japan
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Ohta Yuuki
Department of Nephrology, Sasebo General Hospital, Japan
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Shinzato Takeaki
Department of Internal Medicine, Association of Far-off Islands Hospitals in Nagasaki Prefectural Goto Central Hospital
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