Premature Atherosclerosis in a Japanese Diabetic Patient with Atypical Familial Partial Lipodystrophy and Hypertriglyceridemia

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概要

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• We herein report a case of premature atherosclerosis in a patient with familial partial lipodystrophy (FPL), diabetes mellitus, hypertension and hypertriglyceridemia. Sequencing of the candidate genes LMNA, PPARG and CAV1 associated with FPL revealed no genetic abnormalities, which indicated the activity of a novel gene in this patient. The patient's son showed milder fat loss and similar fat distribution compared to the proband; however, the son showed no signs of any atherosclerotic disease. Although a cluster of atherogenic risk factors is likely to be the primary causes of atherosclerosis in our patient, other factors, including an unknown gene associated with FPL, the severity of fat loss and gender, might affect the development of atherosclerosis.

著者

• Ebihara Ken

  Department Of Medicine And Clinical Science Kyoto University Graduate School Of Medicine

• Nakao Kazuwa

  Department Of Endcrinology And Metabolism Kyoto University Graduate School Of Medicine

• Hosoda Kiminori

  Department Of Endcrinology And Metabolism Kyoto University Graduate School Of Medicine

• Hosoda Kiminori

  Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan

• Tsuji Atsushi

  Department of Neurosurgery, Kusatsu General Hospital, Japan

• Ebihara Ken

  Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan

• Iwanishi Masanori

  Diabetes and Endocrine Division, Kusatsu General Hospital, Japan

• Kusakabe Toru

  Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan

• Harada Shinji

  Diabetes and Endocrine Division, Kusatsu General Hospital, Japan

• Ito-Kobayashi Jun

  Diabetes and Endocrine Division, Kusatsu General Hospital, Japan

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