Recurrence of Chronic Active Epstein-Barr Virus Infection from Donor Cells after Achieving Complete Response Through Allogeneic Bone Marrow Transplantation
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概要
- 論文の詳細を見る
We report the case of a 35-year-old woman with chronic active Epstein-Barr virus (EBV) infection (CAEBV). She underwent allogeneic bone marrow transplantation (BMT) from an unrelated male donor and achieved a complete response. However, her CAEBV relapsed one year after BMT. EBV-infected cells proliferated clonally and revealed a 46XY karyotype. In addition, the infecting EBV strain differed from that detected before BMT. These findings indicated that her disease had developed from donor cells. This is the first report of donor cell-derived CAEBV that recurred after transplantation, suggesting that host factors may be responsible for the development of this disease.
著者
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Harigai Masayoshi
Department Of Medicine And Rheumatology Graduate School Tokyo Medical And Dental University
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Arai Ayako
Department Of Hematology Tokyo Medical And Dental University
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Wake Atsushi
Department Of Hematology Toranomon Hospital
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Ota Yasunori
Department Of Pathology Toranomon Hospital
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Kurosu Tetsuya
Department Of Hematology Tokyo Medical And Dental University
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Imadome Ken-ichi
Department Of Infectious Diseases National Research Institute For Child Health And Development
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Miura Osamu
Department Of Ecology And Evolutionary Biology Graduate School Of Life Sciences University Of Tohoku
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Fujiwara Shigeyoshi
Department Of Infectious Diseases National Research Institute For Child Health And Development
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Yamamoto Hisashi
Department Applied Chemistry Nagoya University
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WU Nan
Department of Material Chemistry, Graduate School of Engineering, Kyoto University
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Kurosu Tetsuya
Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
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Wang Ludan
Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
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Harigai Masayoshi
Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
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Wu Nan
Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
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