The Effect of Methylcobalamin on the Experimental Acrylamide Neuropathy:Morphometric Study

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概要

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• This study was designed to evaluate the effect of methylcobalamin on the myelinated fiber degeneration produced by acrylamide intoxication in rats. Twelve Sprague-Dawley rats were fed a stock diet with water containing 500ppm acrylamide ad libitum for three weeks. During additional three weeks, the acryl amide was withdrawn.<BR>Methylcobalamin, 500μg/kg, was intramuscularly administered to 6 rats as the test and 0.675% NaCl solution was intramuscularly administered to 6 rats as the control for the period of 6 weeks. All rats developed a waddling and paretic gait after twelve days of intoxication. In the control, two rats died on the 19 th and 20th days of intoxication, respectively. No rats died in the test. Three test and two control rats were sacrificed at a time, and both the sural and the peroneal nerves harvested were processed for morphometric studies at the end of the 3rd and 6th weeks of the experiment.<BR>In teased fiber analysis the frequency of axonal degeneration of myelinatedfibers was lower in tests than in control rats for each of four different nerves (the proximal, at midthigh, and distal, at ankle, sural nerves and proximal, at mid thigh, and distal, at knee, peroneal nerves). It was significantly lower in test than in control rats (p<0.02) in the combined test of the four different nerves. Although the density of myelinated fibers was higher in test than in control rats, the difference between the test and control rats was not significant. The total number of myelinated fibers in test rats was significantly greater than in control rats for both proximal and distal sural nerves (p<0.05 and p<0.01).<BR>The data suggested that methylcobalamin may have played a protective role against the axonal degeneration and subsequent loss of myelinated fibers in acrylamide neuropathy of rats.

• 一般社団法人 日本臨床薬理学会の論文

著者

• 大郷 利治

  エーザイK.K .生物研究所

• 大郷 利治

  エーザイK. K. 安全性研究部

• 黒岩 義五郎

  九州大学医学部神経内科

• 大西 晃生

  九州大学医学部脳研神経病理

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