Diuretic Activity of Piretanide:Intravenous Dose Equivalence of Piretanide Injection to Bumeta-nide Injection in Liver Cirrhosis Patients

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The diuretic activity of piretanide injection was compared with that of bumetanide injection in 6 patients with liver cirrhosis. Drugs were allotted according to a single-blind Latin square design. The following conclusions were obtained: 1. For each drug the diuretic effect reached a maximun within 2 hours after intravenous administration, and in 4 hours the effect largely disappeared . 2. Six mg of piretanide was found to be almost equivalent to 0.5 mg of bumetanide with respect to the effects upon urinary volume and Na+ excretion. 3. The electrolyte excretion pattern obtained with piretanide was similar to that of bumetanide. 4. No changes in symptoms, abnormal laboratory data, or untoward effects were noted with either drug.
一般社団法人日本臨床薬理学会の論文