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The effect of mecobalamin on the regenerating process of myelinated fibers in ex-perimental toxic neuropathy induced by antituberculous drug ethambutol was studied.<BR>Seven rats were given 300mg/kg of ethambutol orally every day for nine months. Then they were divided into two groups. Three rats were administered 1, 000μg/kg of mecobalamin intramuscularly three times a week for the following four months (ex-perimental group). The other four were kept untreated for the same period (EB con-trol group). As untreated controls, four normally fed rats of the same age were also examined.<BR>All rats were sacrificed by perfusion with 2% glutaraldehyde solution. Sciatic nerves at midthigh level and tibial nerves at ankle level were removed and examined by teased-fiber method.<BR>The frequency of myelinated fibers showing axonal degeneration with linear rows of myelin ovoids was not different among experimental, EB control and untreated con-trol groups. However, the frequency of fibers showing regeneration after axonal de-generation was significantly higher in both sciatic and tibial nerves of the ex-perimental group than of the EB control group (p<0.02 and p<0.01) and untreated control group (p<0.001). These fibers had uniformly very short internodal lengths, all of which were less than half of the expected length judging from the standard re-gression line between nerve fiber diameter and internodal length.<BR>The result suggested that mecobalamin has a promoting role in the regeneration af-ter axonal degeneration in experimental ethambutol neuropathy.
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松岡幸彦
名古屋大学

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