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Carteolol, a new beta-adrenergic blocking drug with intrinsic sympathomimetic activity, and pindolol were compared in 18 normal men in terms of heart rate, blood pressure, double products, cardiac output, stroke index, cardiac work and systemic vascular resistance.<BR>Carteolol decreased the resting heart rate (p<0.01) to a greater extent than pindolol. At the same supine exercise level there was no difference in the exercise heart rate between both drugs. Carteolol did not significantly decrease the resting and exercise systolic blood pressure, while pindolol decreased both blood pressures (p<0.05). The double products decreased with carteolol on exercise; with pindolol double products decreased at rest as well as on exercise (p<0.05). The resting cardiac output was not changed significantly with pindolol, but decreased with carteolol (p<0.01). At each exercise level both drugs decreased the exercise cardiac output to the same extent (p<0.01). Pindolol did not appreciably decrease the stroke index in contrast to carteolol which reduced the resting stroke index (p<0.05). Both pindolol and carteolol reduced the resting and exercise cardiac work with no significant difference between them. Systemic vascular resistance was not significantly changed at rest as well as on exercise with pindolol and increased with carteolol at rest (p<0.01) and on exercise (p<0.001).<BR>It may be concluded that the efficacy of carteolol lies somewhere between that of pindolol and propranolol as to its intrinsic symapathomimetic action.
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