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To compare adverse reactions due to zimelidine (ZMD) and imipramine (IMP), double blind control trials were performed in healthy young (mean age: 23.4 years) male volunteers. Influence on self-ratings and physiological measurements were compared in cross-over fashion between a single oral administration of ZMD 50 mg and that of IMP 25 mg, and ZMD 100 mg and IMP 50 mg, respectively. ZMD hardly changed heart rate, but IMP 50 mg induced tachycardia 3 to 24 hrs after the administration. ZMD did not influence systolic blood pressure. On the other hand, IMP 50 mg decreased systolic blood pressure and there was a significant difference between the two drugs 4 hrs after the administration (p<0.05). Postual hypotention was recognized in the case of IMP administration. ZMD 100mg decreased critical fusion frequency of flicker less than IMP 50mg (p<0.05-0.01). ZMD did not influence salivary rate, but after IMP 25 mg or 50 mg of IMP intense decrease of salivary rate was observed. There were no significant differences after the two drugs in the measurements of function of equibrium, tapping rate, accomodation width and standing ability on one foot.
一般社団法人日本臨床薬理学会の論文